| 韩苗苗,袁建军,申凯凯,张喜君,李杨,赵婧革,郭艳艳,朱好辉.基于射频信号全息血管硬度分析评价终末期肾病合并高尿酸血症患者颈动脉弹性[J].中国医学影像技术,2022,38(5):684~688 |
| 基于射频信号全息血管硬度分析评价终末期肾病合并高尿酸血症患者颈动脉弹性 |
| Radio frequency-data based quantitative analysis of vessel stiffness for evaluation on carotid elasticity in patients with end-stage renal disease complicated with hyperuricemia |
| 投稿时间：2021-08-27 修订日期：2021-12-06 |
| DOI：10.13929/j.issn.1003-3289.2022.05.011 |
| 中文关键词: 肾衰竭,慢性 肾透析 高尿酸血症 颈动脉 超声检查 |
| 英文关键词:kidney failure, chronic renal dialysis hyperuricemia carotid arteries ultrasonography |
| 基金项目:河南省卫健委省部共建项目(SB201901093)。 |
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| 中文摘要: |
| 目的 以基于射频信号的全息血管硬度分析(R-QVS)技术评价接受维持性血液透析(MHD)治疗终末期肾病(ESRD)合并高尿酸血症患者颈动脉弹性。方法 纳入61例接受MHD的ESRD患者(ESRD组),根据血尿酸(SUA)水平将其分为高SUA亚组(n=31)及正常SUA亚组(n=30),另以35名健康人为对照组,测量并计算其6个心动周期双侧颈总动脉内-中膜厚度(IMT)均值,以R-QVS技术测量收缩期直径(Diam)、血管位移(Dist)和脉搏波传导速度(PWV)及硬度系数(HC);评价各指标测量结果的一致性,比较组间各指标差异,并进行相关性分析。结果 观察者间及观察者内测量颈总动脉各参数的一致性均较好,组内相关系数为0.89~0.93(P均＜0.05)。双侧颈总动脉IMT、Diam、Dist、PWV及HC组间差异均无统计学意义(P均＞0.05)。双侧颈动脉参数均值中,高SUA亚组、正常SUA亚组与对照组IMT、Dist差异均无统计学意义(P均＞0.05);高SUA亚组和正常SUA亚组Diam、PWV及HC均高于对照组(P均＜0.05);高SUA亚组Diam、PWV及HC均高于正常SUA亚组(P均＜0.05)。ESRD组颈总动脉PWV与透析龄、脉压、SUA及病程均呈正相关(r=0.70、0.72、0.54、0.58,P均＜0.05),与其他临床指标均无明显相关(P均＞0.05)。结论 接受MHD治疗的ESRD患者颈动脉弹性降低早于其形态改变,合并高尿酸血症者更显著。 |
| 英文摘要: |
| Objective To observe the carotid elasticity in patients of end-stage renal disease (ESRD) complicated with hyperuricemia treated with maintenance hemodialysis (MHD) with radio frequency-data based quantitative analysis of vessel stiffness (R-QVS).Methods Sixty-one ESRD patients underwent MHD (ESRD group) were enrolled and divided into high SUA subgroup (n=31) and normal SUA subgroup (n=30) according to the level of serum uric acid (SUA). Meanwhile, 35 healthy people were taken as controls (control group). The mean intima-media thickness (IMT) of bilateral common carotid arteries during 6 cardiac cycles were measured and calculated, and systolic diameter (Diam), vascular displacement (Dist), pulse wave velocity (PWV) and hardness coefficient (HC) were measured with R-QVS technique. The consistency of measurements of the above indexes were evaluated and compared between subgroups and/or groups, and the correlations were analyzed.Results The inter-observer and intra-observer consistency of measurements of common carotid artery parameters were all good, with 0.89－0.93 (all P＜0.05). There was no significant difference of IMT, Diam, Dist, PWV nor HC in all subjects (all P＞0.05).There was no significant difference of IMT nor Dist between high SUA subgroup, normal SUA subgroup and control group (all P＞0.05). Diam, PWV and HC in high SUA subgroup and normal SUA subgroup were higher than those in control group (all P＜0.05), while Diam, PWV and HC in high SUA subgroup were higher than those in normal SUA subgroup. In ESRD group (all P＜0.05), PWV of carotid artery was positively correlated with the history of dialysis, pulse pressure difference, SUA and course of disease (r=0.70, 0.72, 0.54, 0.58, all P＜0.05), but no significant correlation with other clinical indicators was found (all P＞0.05).Conclusion Decrease of carotid elasticity in ESRD patients underwent MHD was earlier than morphological changes, which was more significant in patients with hyperuricemia. |
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