| 柯明星,韩兆国,孙夕林.基于间质表皮转化因子/肝细胞生长因子信号通路靶向分子成像探针研究进展[J].中国医学影像技术,2022,38(4):624~627 |
| 基于间质表皮转化因子/肝细胞生长因子信号通路靶向分子成像探针研究进展 |
| Research progresses of targeted molecular imaging probes based on c-mesenchymal-epithelial transition factor/hepatocyte growth factor signal pathway |
| 投稿时间：2020-12-21 修订日期：2021-10-14 |
| DOI：10.13929/j.issn.1003-3289.2022.04.036 |
| 中文关键词: 分子探针技术 分子成像 间质表皮转化因子 肝细胞生长因子 |
| 英文关键词:molecular probe techniques molecular imaging c-mesenchymal-epithelial transition factor hepatocyte growth factor |
| 基金项目:国家自然科学基金（81627901）。 |
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| 中文摘要: |
| 间质表皮转化因子（c-Met）/肝细胞生长因子（HGF）信号通路在肿瘤发生、发展中起重要作用。分子成像可准确、无创地评价关键分子靶点在体表达水平和活化状态。基于c-Met的肿瘤靶向分子成像不仅可检测c-Met表达状态以筛选受益患者，还能监测治疗效果、评估预后，提高靶向治疗效果。本文就基于c-Met/HGF信号通路的靶向分子成像探针研究进展进行综述。 |
| 英文摘要: |
| C-mesenchymal-epithelial transition factor (c-Met)/hepatocyte growth factor (HGF) signal pathway plays an important role in tumorigenesis and development. Molecular imaging can accurately and non-invasively evaluate the in vivo expression level and activation status of key molecular targets. Molecular imaging based on c-Met for tumors could not only detect the expression status of c-Met to screen beneficial patients, but also monitor therapeutic effect and evaluate prognosis, hence improving the effect of targeted therapy. The research progresses of targeted molecular imaging probes based on c-Met/HGF signaling pathway were reviewed in this article. |
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