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2025-06-14 星期六
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王洁,庞华,夏铸,雷成明,贾建华.比较¹⁸F-氟代胆碱PET/CT、⁹⁹Tc^m-甲氧基异丁基异腈SPECT/CT及超声诊断甲状旁腺功能亢进症[J].中国医学影像技术,2022,38(3):358~362

比较¹⁸F-氟代胆碱PET/CT、⁹⁹Tc^m-甲氧基异丁基异腈SPECT/CT及超声诊断甲状旁腺功能亢进症

Comparison on ¹⁸F-fluorocholine PET/CT, ⁹⁹Tc^m-methoxyisobutylisonitrile SPECT/CT and ultrasound for diagnosing hyperparathyroidism

投稿时间：2020-04-20 修订日期：2021-12-30

DOI：10.13929/j.issn.1003-3289.2022.03.010

中文关键词: 甲状旁腺功能亢进症正电子发射断层显像体层摄影术,发射型计算机,单光子 18F氟脱氧葡萄糖氟胆碱

英文关键词:hyperparathyroidism positron-emission tomography tomography, emission-computed, single-photon fluorodeoxyglucose F18 fluorine choline

基金项目:

作者	单位	E-mail
王洁	重庆医科大学附属第一医院核医学科, 重庆 400016	624289942@qq.com
庞华	重庆医科大学附属第一医院核医学科, 重庆 400016
夏铸	重庆医科大学附属第一医院核医学科, 重庆 400016
雷成明	重庆医科大学附属第一医院核医学科, 重庆 400016
贾建华	重庆医科大学基础医学院放射医学与肿瘤学实验室, 重庆 400016

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中文摘要:

目的比较¹⁸F-氟代胆碱（FCH） PET/CT、⁹⁹Tc^m-甲氧基异丁基异腈（MIBI） SPECT/CT及超声（US）诊断甲状旁腺功能亢进症（HPT）的效能。方法回顾性分析34例HPT患者，术前2个月内均接受¹⁸F-FCH PET/CT、⁹⁹Tc^m-MIBI SPECT/CT及US检查；以术中及术后病理结果为参考，评估并比较各方法的诊断效能。结果于34例共切除90处甲状旁腺病灶，病理证实其中81处为甲状旁腺增生或腺瘤组织，7处为甲状腺组织，2处为淋巴结。¹⁸F-FCH PET/CT诊断HPT的敏感度、特异度、阳性预测值、阴性预测值及准确率分别为85.19%（69/81）、100%（55/55）、100%（69/69）、82.09%（55/67）及91.18%（124/136），⁹⁹Tc^m-MIBI SPECT/CT分别为74.07%（60/81）、90.91%（50/55）、92.31%（60/65）、70.42%（50/71）及80.88%（110/136），US分别为65.43%（53/81）、98.18%（54/55）、98.15%（53/54）、65.85%（54/82）及78.68%（107/136）。¹⁸F-FCH PET/CT诊断HPT的效能高于⁹⁹Tc^m-MIBI SPECT/CT和US （Z=2.290，P=0.022；Z=2.496，P=0.013）。结论 ¹⁸F-FCH PET/CT、⁹⁹Tc^m-MIBI SPECT/CT及US 3种方法中，¹⁸F-FCH PET/CT诊断HPT的效能最高。

英文摘要:

Objective To compare the efficacy of ¹⁸F-fluorocholine (FCH) PET/CT, ⁹⁹Tc^m-methoxyisobutylisonitrile (MIBI) SPECT/CT and ultrasound (US) for diagnosing hyperparathyroidism (HPT). Methods Data of 34 patients with HPT who underwent ¹⁸F-FCH PET/CT, ⁹⁹Tc^m-MIBI SPECT/CT and US within 2 months before surgical operations were retrospectively analyzed. Taken intraoperative and postoperative pathologic findings as the referent standards, the diagnostic efficacy of the above 3 methods were evaluated and compared. Results Totally 90 lesions were excised from 34 patients, 81 of which were confirmed to be parathyroid hyperplasia or adenoma tissue, whereas 7 were thyroid tissue and 2 were lymph nodes. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy of ¹⁸F-FCH PET/CT for diagnosing HPT was 85.19% (69/81), 100% (55/55), 100% (69/69), 82.09% (55/67) and 91.18% (124/136), respectively, of ⁹⁹Tc^m-MIBI SPECT/CT was 74.07% (60/81), 90.91% (50/55), 92.31% (60/65), 70.42% (50/71) and 80.88% (110/136), respectively, and of US was 65.43% (53/81), 98.18% (54/55), 98.15% (53/54), 65.85% (54/82) and 78.68% (107/136), respectively. The diagnostic efficacy of ¹⁸F-FCH PET/CT for HPT was higher than that of ⁹⁹Tc^m-MIBI SPECT/CT and US (Z=2.290, P=0.022; Z=2.496, P=0.013). Conclusion Among ¹⁸F-FCH PET/CT, ⁹⁹Tc^m-MIBI SPECT/CT and US, ¹⁸F-FCH PET/CT had the highest diagnostic efficacy of HPT.

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