| 鲍志国,周青,赵森,杜森,方建,王大勇.多探针PET成像观察轻度认知障碍[J].中国医学影像技术,2022,38(2):177~181 |
| 多探针PET成像观察轻度认知障碍 |
| Multi-tracer PET imaging observation on mild cognitive impairment |
| 投稿时间：2020-05-23 修订日期：2021-08-10 |
| DOI：10.13929/j.issn.1003-3289.2022.02.005 |
| 中文关键词: 认知障碍 阿尔茨海默病 神经原纤维缠结 淀粉样β肽 正电子发射断层显像 |
| 英文关键词:cognition disorders Alzheimer disease neurofibrillary tangles amyloid beta-peptides positron-emission tomography |
| 基金项目:河南省医学科技攻关计划（2017T02048）。 |
|
| 摘要点击次数: 1993 |
| 全文下载次数: 649 |
| 中文摘要: |
| 目的 观察轻度认知障碍患者（MCI）β淀粉样蛋白（Aβ）斑块、tau蛋白沉积和FDG PET特征。方法 自ADNI数据库下载半年内接受Aβ-PET、tau-PET和FDG-PET成像的40例MCI患者及30名健康人（NC组），基于视觉判断其有/无皮层Aβ滞留，并据此将MCI患者分为Aβ+ MCI组和Aβ-MCI组。分别对Aβ+ MCI组和Aβ-MCI组与NC组进行逐像素统计分析，提取Aβ+ MCI组AD特征脑区的平均图像强度值，分析FDG与Aβ斑块和tau蛋白沉积的相关性。结果 相比NC组，Aβ+ MCI组Aβ斑块呈全脑弥漫升高，边缘系统和新皮层tau蛋白对称性沉积增加，双侧扣带回、顶叶及楔前叶FDG代谢降低；FDG摄取与Aβ斑块无明显相关（P均>0.05），在杏仁核（r=－0.56，P<0.01）、扣带回后部（r=－0.61，P<0.01）、海马（r=－0.45，P=0.04）、海马旁回（r=－0.51，P=0.02）、楔前叶（r=－0.49，P=0.02）和颞中回（r=－0.53，P=0.01）与tau蛋白沉积呈负相关，在顶叶亦无明显相关（r=0.01，P=0.97）。Aβ-MCI组Aβ斑块和tau蛋白沉积低于NC组。结论 Aβ+ MCI具有阿尔茨海默病（AD）的PET特征，可视为AD前驱阶段。 |
| 英文摘要: |
| Objective To observe PET characteristics of amyloid-β (Aβ) plaque, tau proteinosis and FDG in patients with mild cognitive impairment (MCI). Methods Forty patients with MCI and 30 normal subjects (NC group) were recruited from ADNI database. All subjects underwent multi-tracer PET imaging, comprising Aβ-PET, tau-PET and FDG-PET. According to visually comprising evaluation of whether there was Aβ plaque or not in cortex, MCI patients were divided into Aβ+ MCI group and Aβ-MCI group. Then all the subjects were statistically analyzed pixel by pixel, and the average image intensity of AD characteristic brain areas in Aβ+ MCI group was extracted. Correlations between FDG Aβ plaques and tau proteinosis were analyzed, respectively. Results Compared with NC group, Aβ plaques increased through whole brain in Aβ+ MCI group, while symmetrical deposition of tau increased in bilateral limbic system and neocortex, and hypo-metabolism of FDG decreased in bilateral cingulate gyrus, parietal lobe and precuneus. No obvious correlation was found between FDG and Aβ plaques (all P>0.05). Significant negative correlations were found between FDG and tau proteinosis in amygdala (r=-0.56, P<0.01), posterior cingulate gyrus (r=-0.61, P<0.01), hippocampus (r=-0.45, P=0.04), parahippocampal gyrus (r=-0.51, P=0.02), precuneus (r=-0.49, P=0.02) and middle temporal gyrus (r=-0.53, P=0.01), but not in parietal lobe (r=0.01, P=0.97). Aβ plaques and tau proteinosis in Aβ-MCI group were lower than those in NC group. Conclusion Aβ+ MCI patients had PET characteristics similar to Alzheimer's disease (AD), and could be regarded as the precursor stage of AD. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
