| 操纵,余永强,陈先文,王尚培.静息态功能MRI观察帕金森病伴疲劳患者局部一致性及功能连接[J].中国医学影像技术,2021,37(12):1814~1818 |
| 静息态功能MRI观察帕金森病伴疲劳患者局部一致性及功能连接 |
| Resting state functional MRI observation on regional homogeneity and functional connectivity in Parkinson disease patients with fatigue |
| 投稿时间：2021-02-05 修订日期：2021-06-15 |
| DOI：10.13929/j.issn.1003-3289.2021.12.014 |
| 中文关键词: 帕金森病 疲劳 磁共振成像 局部一致性 功能连接 |
| 英文关键词:Parkinson disease fatigue magnetic resonance imaging regional homogeneity functional connectivity |
| 基金项目:国家自然科学基金面上项目（81771817）。 |
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| 中文摘要: |
| 目的 观察帕金森病（PD）伴疲劳（PD-F）患者局部一致性（ReHo）及功能连接（FC），探索其局部脑区分离功能和连接功能。方法 纳入29例PD-F患者（PD-F组）和29例PD不伴疲劳（PD-NF）患者（PD-NF组），以35名健康对照者为对照（HC组）；采集静息态功能MRI（fMRI），完成临床量表评估；计算ReHo，并分析其与疲劳严重程度量表（FSS）评分的相关性；将2组患者ReHo值存在差异且与FSS相关脑区设为ROI，观察全脑体素水平FC。结果 PD-F组右侧罗兰迪克岛盖ReHo值显著降低（体素P=0.001，总体错误率校正P<0.05）；PD组右侧罗兰迪克岛盖ReHo值与FSS评分呈负相关（r=-0.539，P<0.001）。PD-F组右侧罗兰迪克岛盖与双侧中扣带回的FC减弱（体素P=0.001，FWE校正P<0.05）。结论 PD-F患者右侧罗兰迪克岛盖脑区分离功能且与双侧中扣带回FC异常，并均参与PD-F病理生理机制。 |
| 英文摘要: |
| Objective To observe regional homogeneity (ReHo) and functional connectivity (FC) in patients of Parkinson disease (PD) with fatigue (PD-F), and to explore the separation function and connectivity function of PD-F local brain regions. Methods Totally 29 PD-F patients (PD-F group), 29 PD without fatigue (PD-NF) patients (PD-NF group) and 35 age and gender matched healthy controls (HC group) were enrolled. All subjects underwent clinical scale evaluation and resting-state functional MRI (fMRI). ReHo was calculated and correlated with the fatigue severity scale (FSS). The brain regions with ReHo differences between PD-F and PD-NF groups and correlated to FSS were set as ROI for FC of the whole brain voxel level. Results ReHo of right Rolandic operculum in PD-F group significantly decreased (voxel P=0.001, family wise error rate correction, P<0.05). ReHo values of right Rolandic operculum in all PD patients were negatively correlated with FSS (r=-0.539, P<0.001). In PD-F group, FC between right Rolandic operculum and bilateral middle cingulate gyrus decreased (voxel P=0.001, FWE correction, P<0.05). Conclusion The dysfunction of right Rolandic operculum local brain region and relative abnormal FC with bilateral middle cingulate gyrus were involved in the pathophysiological mechanism of PD-F. |
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