| 汤泊,周东亚,刘敏,李天女,丁重阳.18F-FDG PET/CT测算病灶糖酵解总量预测食管癌患者经放射及化学治疗预后[J].中国医学影像技术,2021,37(11):1680~1684 |
| 18F-FDG PET/CT测算病灶糖酵解总量预测食管癌患者经放射及化学治疗预后 |
| 18F-FDG PET/CT measurement of total lesion glycolysis for predicting prognosis of patients with esophageal cancer after radiotherapy and chemotherapy |
| 投稿时间：2021-01-02 修订日期：2021-08-04 |
| DOI：10.13929/j.issn.1003-3289.2021.11.021 |
| 中文关键词: 食管肿瘤 正电子发射断层显像 体层摄影术,X线计算机 氟脱氧葡萄糖F18 |
| 英文关键词:esophageal neoplasms positron-emission tomography tomography, X-ray computed fluorodeoxyglucose F18 |
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| 中文摘要: |
| 目的 观察18F-FDG PET/CT测算病灶糖酵解总量（TLG）预测食管癌患者经放射化学治疗（简称放化疗）后预后的价值。方法 回顾性分析131例接受放化疗的食管癌患者的临床资料、治疗前18F-FDG PET/CT资料及随访资料。绘制受试者工作特征（ROC）曲线，计算曲线下面积（AUC），观察肿瘤最大标准摄取值（SUVmax）、原发病灶TLG（TLGp）及全身病灶TLG（TLGwb）等评估预后的价值。结果 131例食管癌均表现为18F-FDG高摄取，原发灶SUVmax、TLGp和TLGwb分别为16.29（7.52，30.12）、90.15（17.68，501.89）及150.55（22.69，798.87）。随访期内63例患者死于食管癌。根据SUVmax、TLGp及TLGwb预测患者总生存期的最佳截断值分别为12.59、84.03及176.10。N分期、M分期及TLGwb是影响预后的独立危险因素（P均<0.05）。TLGwb ≤ 176.10患者3年总生存率明显高于TLGwb>176.10者（P<0.001）。结论 食管癌放化疗前18F-FDG PET/CT测算的TLGwb及N分期和M分期是影响患者预后的独立危险因素；TLGwb>176.10提示预后较差。 |
| 英文摘要: |
| Objective To observe the value of 18F-FDG PET/CT measurement of total lesion glycolysis (TLG) for predicting prognosis of patients with esophageal cancer after radiotherapy and chemotherapy. Methods Clinical data, 18F-FDG PET/CT data before and after radiotherapy and chemotherapy and during following-up of 131 esophageal cancer patients were retrospectively analyzed. The receiver operating characteristic (ROC) curve was drawn, the area under the curve (AUC) was calculated to observe the value of the maximum standardized uptake value (SUVmax), TLG of primary lesion (TLGp) and whole-body TLG (TLGwb) for evaluating prognosis of these patients. Results The primary lesions of all 131 cases showed high 18F-FDG uptakes, and the SUVmax, TLGp and TLGwb was 16.29(7.52, 30.12), 90.15(17.68, 501.89) and 150.55(22.69, 798.87), respectively. During following-up, 63 patients died of esophageal cancer. The best cut-off value of SUVmax, TLGp and TLGwb for predicting overall survival was 12.59, 84.03 and 176.10, respectively. N stage, M stage and TLGwb were all independent risk factors for prognosis (all P<0.05). The 3-year overall survival rate of patients with TLGwb ≤ 176.10 was significantly higher than that of patients with TLGwb>176.10 (P<0.001). Conclusion Before treatment, 18F-FDG PET/CT measurement of TLGwb, N stage and M stage were independent risk factors for prognosis of esophageal cancer patients after radiotherapy and chemotherapy. TLGwb>176.10 indicated poor prognosis. |
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