| 刘红红,刘家金,王瑞民,徐白萱,姚树林.18F-FDGPET/MRI评估宫颈癌大小、分化程度、肌层浸润深度和周围组织受累[J].中国医学影像技术,2021,37(11):1619~1623 |
| 18F-FDGPET/MRI评估宫颈癌大小、分化程度、肌层浸润深度和周围组织受累 |
| 18F-FDG PET/MRI evaluation on the size, differentiation degree, myometrial invasion depth and surrounding tissue involvement of cervical cancer |
| 投稿时间：2021-04-14 修订日期：2021-09-13 |
| DOI：10.13929/j.issn.1003-3289.2021.11.006 |
| 中文关键词: 子宫颈肿瘤 正电子发射断层显像 磁共振成像 18F氟脱氧葡萄糖 |
| 英文关键词:uterine cervical neoplasms positron-emission tomography magnetic resonance imaging fluorodeoxyglucose F18 |
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| 中文摘要: |
| 目的 观察18F-FDG PET/MRI病灶最大标准摄取值（SUVmax）和最小表观弥散系数（ADCmin）评估宫颈癌大小、分化程度、肌层浸润深度和累及周围组织的价值。方法 回顾性分析45例宫颈癌患者的PET/MRI，根据术后病理将其分为中-高分化组（n=20）和低分化组（n=25）；测量病灶长径和短径，并计算病灶平均径、SUVmax及ADCmin，观察SUVmax和ADCmin评估宫颈癌大小、分化程度、肌层浸润深度及周围组织受累的效能。结果 45例宫颈癌病灶平均径为（27.67±11.53）mm，中-高分化组病灶平均径[(27.68±2.71)mm]与低分化组[(27.67±2.26)mm]差异无统计学意义（P>0.05）。MRI显示15例宫颈肌层浸润深度≤ 1/2肌层，其中11例与病理结果一致；30例浸润深度>1/2肌层，其中28例与病理结果一致；MRI与病理符合率为86.67%（39/45）。病理结果显示10例宫颈癌累及子宫体、3例累及子宫旁脂肪组织、8例累及阴道、3例累及附件；PET/MRI检出率分别为80.00%（8/10）、66.67%（2/3）、75.00%（6/8）和66.67%（2/3）。宫颈癌SUVmax与其平均径呈中度正相关（r=0.536，P<0.01），且中-高分化组SUVmax与低分化组差异无统计学意义（P>0.05）。宫颈癌ADCmin与其平均径呈中度负相关（r=-0.525，P<0.01），且中-高分化组ADCmin明显高于低分化组（P<0.05）。结论 18F-FDG PET/MRI观察病灶SUVmax和ADCmin有助于评估宫颈癌大小、分化程度、肌层浸润深度及周围组织受累，尤以ADCmin价值较高。 |
| 英文摘要: |
| Objective To observe the maximum standard uptake value (SUVmax) and the minimum apparent diffusion coefficient (ADCmin) on 18F-FDG PET/MRI for evaluating the size, differentiation degree, myometrial invasion depth and surrounding tissue involvement of cervical cancer. Methods PET/MRI of 45 patients with cervical cancer were retrospectively analyzed. The patients were divided into medium-high differentiation group (n=20) and low differentiation group (n=25) according to postoperative pathology. The long and short diameter of cervical cancers were measured, and the mean diameter, SUVmax and ADCmin were calculated, the value of SUVmax and ADCmin for evaluating the size, degree of differentiation, depth of myometrial invasion and surrounding tissue involvement of cervical cancer were observed. Results The mean diameter of 45 cervical cancer lesions was (27.67±11.63)mm, and there was no significant difference of the mean diameter between medium-high differentiation group ([27.68±2.71]mm) and low differentiation group ([27.67±2.26]mm, P>0.05). MRI showed myometrial invasion depth of cervical cancer ≤ 1/2 myometrium in 15 cases, including 11 cases being consistent with pathological findings, while >1/2 myometrium 30 cases, including 28 cases being consistent with pathological findings, and the coincidence rate of pathology and MRI was 86.67% (39/45). Pathological results showed involved uterine body in 10 cases, involved parauterine adipose tissue in 3 cases, involved vagina in 8 cases and involved accessories in 3 cases, and MRI detection rate of the above involvements was 80.00% (8/10), 66.67% (2/3), 75.00% (6/8) and 66.67% (2/3), respectively. Moderately positive correlation was detected between SUVmax and the mean diameter of cervical cancer (r=0.536, P<0.01), while there was no significant difference of SUVmax between groups (P>0.05). Moderately negative correlation was found between ADCmin and mean diameter of cervical cancer (r=-0.525, P<0.01), and ADCmin of medium-high differentiation group ([0.744±0.122]×10-3mm2/s) was significantly higher than that of low differentiation group ([0.654±0.132]×10-3mm2/s, P<0.05). Conclusion SUVmax and ADCmin of cervical cancer on 18F-FDG PET/MRI were helpful to evaluating the size, differentiation degree, myometrial invasion depth and surrounding tissue involvement of tumor, especially ADCmin. |
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