| 葛颖,俞梅美,沈慧聪.2-羟基戊二酸在异柠檬酸脱氢酶突变型胶质瘤发生、发展中的作用及磁共振波谱检测方法[J].中国医学影像技术,2021,37(8):1246~1250 |
| 2-羟基戊二酸在异柠檬酸脱氢酶突变型胶质瘤发生、发展中的作用及磁共振波谱检测方法 |
| 2-hydroxyglutarate in the occurrence and development of isocitrate dehydrogenase mutant gliomas and detectionmethods by magnetic resonance spectroscopy |
| 投稿时间：2020-05-13 修订日期：2021-06-01 |
| DOI：10.13929/j.issn.1003-3289.2021.08.032 |
| 中文关键词: 胶质瘤 异柠檬酸脱氢酶 α-羟基戊二酸 磁共振波谱 |
| 英文关键词:glioma isocitrate dehydrogenase alpha-hydroxyglutarate magnetic resonance spectroscopy |
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| 中文摘要: |
| 异柠檬酸脱氢酶（IDH）是WHO中枢神经系统肿瘤分类中最重要的分子表型参数之一。作为IDH突变型胶质瘤的特征性代谢产物，2-羟基戊二酸（2-HG）可从多方面影响肿瘤发生、发展及侵袭过程。磁共振波谱（MRS）为无创性检测2-HG的影像学手段，通过改进技术及优化判读指标，可改善MRS对2-HG谱峰的显示能力并拓展其临床应用范围。本文对2-HG在IDH突变型胶质瘤发生、发展中的作用及其MRS检测方法进展进行综述。 |
| 英文摘要: |
| Isocitrate dehydrogenase (IDH) is one of the most important molecular parameters of WHO classification of central nervous system tumors. As a characteristic metabolite of IDH mutant gliomas, 2-hydroxyglutarate (2-HG) plays a crucial role in the procedure of occurrence, development and invasion of tumors. Magnetic resonance spectroscopy (MRS) is a non-invasive detection method of 2-HG. Through the improvement of technology and the optimization of interpretation indexes, the ability of MRS for showing the peak of 2-HG will be improved, and the scope of its clinical application will be expanded. The role of 2-HG in the occurrence and development of IDH mutant glioma and the progresses of MRS for detecting 2-HG were reviewed in this paper. |
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