| 何垚,杨龙,袁建军,朱好辉,邵黎阳.原发性肝癌超声造影血流灌注参数与肿瘤分化程度及微血管生成的关系[J].中国医学影像技术,2021,37(8):1177~1181 |
| 原发性肝癌超声造影血流灌注参数与肿瘤分化程度及微血管生成的关系 |
| Relationships of contrast-enhanced ultrasound blood perfusion parameters, differentiation and microangiogenesis of primary hepatic carcinoma |
| 投稿时间：2019-10-20 修订日期：2021-04-26 |
| DOI：10.13929/j.issn.1003-3289.2021.08.014 |
| 中文关键词: 癌,肝细胞 超声检查 造影剂 时间-强度曲线 微血管密度 |
| 英文关键词:carcinoma, hepatocellular ultrasonography contrast media time-intensity curve microvessel density |
| 基金项目:河南省医学科技攻关计划项目（2018020431）。 |
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| 中文摘要: |
| 目的 分析原发性肝癌（PHC）超声造影（CEUS）血流灌注参数与肿瘤分化程度及微血管生成的关系。方法 回顾性分析120例PHC患者（120个病灶），术前均接受CEUS检查，记录动脉相血流灌注参数；术后测定微血管密度（MVD），并进行病理分级。对比不同病理分级PHC的CEUS动脉相血流灌注参数及灌注模式，分析MVD与血流灌注参数的相关性。结果 120个PHC病灶中，高分化39个，中分化44个，低分化37个；其中动脉相达峰时间、增强时间、始退时间、廓清时间、平均血流密度（MFD）差异均有统计学意义（P均<0.05）。不同分化程度PHC动脉相具有不同血流灌注模式，高、中、低分化PHC分别以放射样、混合样、蛛网样为主。蛛网样（n=39）、混合样（n=46）、放射样（n=35）PHC的MVD逐渐降低（P均<0.05）。PHC的MVD与MFD呈正相关（r=0.534，P<0.001），与增强时间（r=-0.320，P<0.001）、达峰时间（r=-0.308，P<0.001）及廓清时间（r=-0.389，P<0.001）均呈负相关。结论 CEUS定量血流灌注参数与PHC分化程度及微血管生成密切相关。 |
| 英文摘要: |
| Objective To analyze the relationships of contrast-enhanced ultrasound (CEUS) blood perfusion parameters, differentiation and microangiogenesis of primary hepatic carcinoma (PHC). Methods Data of 120 PHC patients (120 lesions) were retrospectively analyzed. CEUS examination was performed before operation, and the arterial phase blood perfusion parameters of PHC were obtained. The microvessel density (MVD) was measured, and pathological classification of PHC was performed. CEUS arterial phase blood perfusion parameters and perfusion modes of different pathological grade PHC were compared, and the relationships of MVD and blood perfusion parameters were analyzed. Results There were 39 highly differentiated, 44 moderately differentiated and 37 poorly differentiated lesions among 120 PHC. Significant differences of arterial phase peak time, enhancement time, retreat time, clearance time and mean blood flow density (MFD) were found among PHC with different differentiation levels (all P<0.05). The radial perfusion mode was mainly observed in arterial phase of highly differentiated PHC, the mixed type mainly in moderately differentiated lesions and the arachnoid type mainly in poorly differentiated PHC. MVD of PHC gradually decreased in turn of arachnoid type, mixed type and radial type (all P<0.05). MVD of PHC was positively correlated with MFD (r=0.534, P<0.001), and the enhancement time (r=-0.320, P<0.001), peak time (r=-0.308, P<0.001) and clearance time (r=-0.389, P<0.001) were all negatively correlated with MVD. Conclusion CEUS quantitative perfusion parameters of PHC were closely related to the degree of tumor differentiation and microangiogenesis. |
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