| 马玉燕,邓玥,李宗芳,唐丹,曾颖卿,包含,赵琪瑞,赵卫.三维动脉自旋标记联合体素内不相干运动成像鉴别诊断良恶性脑膜瘤[J].中国医学影像技术,2021,37(8):1131~1135 |
| 三维动脉自旋标记联合体素内不相干运动成像鉴别诊断良恶性脑膜瘤 |
| Three-dimensional arterial spin labeling combined with intravoxel incoherent motion imaging for differential diagnosis of benign and malignant meningiomas |
| 投稿时间：2020-05-20 修订日期：2021-02-16 |
| DOI：10.13929/j.issn.1003-3289.2021.08.003 |
| 中文关键词: 脑膜瘤 诊断,鉴别 磁共振成像 体素内不相干运动 动脉自旋标记 |
| 英文关键词:meningioma diagnosis, differential magnetic resonance imaging intravoxel irrelevant motion arterial spin labeling |
| 基金项目:云南省科技厅科技计划、云南省教育厅科学研究基金（2019Y0354）、昆明医科大学研究生创新基金（2019S034）。 |
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| 中文摘要: |
| 目的 观察三维动脉自旋标记（3D-ASL）联合体素内不相干运动（IVIM）成像鉴别诊断良、恶性脑膜瘤的价值。方法 回顾性分析57例经病理证实的脑膜瘤患者，包括43例良性（良性组）及14例恶性（恶性组）脑膜瘤，术前均接受常规、增强MR扫描及MR 3D-ASL、IVIM成像。对比2组相对脑血流量（rCBF）、真扩散系数（D）、假性扩散系数（D*）及灌注分数（f）。采用受试者工作特征（ROC）曲线分析各参数鉴别诊断良、恶性脑膜瘤的效能。结果 恶性组rCBF大于良性组（P<0.05），D小于良性组（P<0.05），2组间D*、f差异均无统计学意义（P均>0.05）。ROC曲线结果显示，阈值取3.027 5 ml/（min·100 g）时，rCBF鉴别诊断良、恶性脑膜瘤的敏感度为92.86%，特异度为74.42%，AUC为0.811；阈值为0.529 5×10-3 mm2/s时，D鉴别诊断良、恶性脑膜瘤的敏感度为88.37%，特异度为64.29%，AUC为0.689；rCBF联合D鉴别诊断良恶性脑膜瘤的敏感度为85.71%，特异度为86.05%，AUC为0.832。结论 3D-ASL联合IVIM成像鉴别诊断良恶性脑膜瘤的价值较高。 |
| 英文摘要: |
| Objective To observe the value of three-dimensional arterial spin labeling (3D-ASL) combined with intravoxel incoherent motion (IVIM) imaging for differential diagnosis of benign and malignant meningiomas. Methods Fifty-seven patients with meningiomas confirmed by pathology who underwent routine MR, enhanced MR, MR 3D-ASL and IVIM scans before operation were retrospectively analyzed, including 43 benign meningiomas (benign group) and 14 malignant meningiomas (malignant group). The relative cerebral blood flow (rCBF), true diffusion coefficient (D), false diffusion coefficient (D*) and perfusion fraction (f) were obtained and compared between groups. The receiver operating characteristic (ROC) curves were drawn to analyze the differential diagnosis efficacy of the above indexes for benign and malignant meningiomas. Results rCBF of malignant group was higher, and D of malignant group was lower than those of benign group (all P<0.05). There was no significant difference of D* nor f between groups (both P>0.05). The ROC curve results showed that when the threshold was 3.027 5 ml/(min·100 g), the sensitivity, specificity and the area under the curve (AUC) of rCBF for distinguishing benign and malignant meningioma was 92.86%, 74.42% and 0.811, respectively. Taken 0.529 5×10-3 mm2/s as the threshold of D,the sensitivity was 88.37%, specificity was 64.29% and AUC was 0.689. Combining rCBF with D, the sensitivity, specificity and AUC for differential diagnosis of benign and malignant meningiomas was 85.71%, 86.05% and 0.832, respectively. Conclusion 3D-ASL combined with IVIM imaging had high value of differential diagnosis of benign and malignant meningiomas. |
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