| 邹云雷,刘小慧,赵云,刘朝奇,刘爱华.超声微泡介导微RNA治疗肝细胞癌的研究进展[J].中国医学影像技术,2021,37(7):1082~1085 |
| 超声微泡介导微RNA治疗肝细胞癌的研究进展 |
| Research progresses of ultrasonic microbubble-mediated microRNA in treatment of hepatocellular carcinoma |
| 投稿时间：2020-04-10 修订日期：2021-04-30 |
| DOI：10.13929/j.issn.1003-3289.2021.07.028 |
| 中文关键词: 癌,肝细胞 微泡 基因,肿瘤 微RNAs 超声检查 |
| 英文关键词:carcinoma, hepatocellular microbubbles genes, neoplasm microRNAs ultrasonography |
| 基金项目: |
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| 中文摘要: |
| 基因治疗正逐渐成为肝细胞癌（HCC）、尤其晚期HCC的治疗方案。足够剂量的特定微RNA（miRNA）可抑制HCC细胞生长，超声微泡介导基因和药物递送治疗策略可促使miRNA于肿瘤区域靶向释放，从而达到治疗效果。本文对超声微泡介导miRNA治疗HCC研究进展进行综述。 |
| 英文摘要: |
| Gene therapy has gradually become an important method for treatment of hepatocellular carcinoma (HCC), especially advanced HCC. A sufficient dose of specific microRNA (miRNA) can inhibit the growth of liver cancer cells, and ultrasound microbubble-mediated gene and drug delivery strategy can promote the targeted release of miRNA in tumor area and achieve therapeutic effect. The research progresses of ultrasound microbubble-mediated miRNA in treatment of HCC were reviewed in this article. |
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