| 陈媛娴,王兴田,刘洁,王玉乔,周文艳.声触诊组织成像定量技术所测剪切波速度与乳腺癌病理分级及分型的关系[J].中国医学影像技术,2021,37(6):895~898 |
| 声触诊组织成像定量技术所测剪切波速度与乳腺癌病理分级及分型的关系 |
| Relationships of shear wave velocity measured with virtual touch tissue imaging quantification technique with pathological classification and typing of breast cancer |
| 投稿时间：2020-04-17 修订日期：2021-02-02 |
| DOI：10.13929/j.issn.1003-3289.2021.06.024 |
| 中文关键词: 乳腺肿瘤 超声检查 剪切波速度 声触诊组织成像量化 病理学 |
| 英文关键词:breast neoplasms ultrasonography shear wave velocity virtual touch tissue imaging quantification pathology |
| 基金项目: |
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| 中文摘要: |
| 目的 观察声触诊组织成像定量（VTIQ）技术所测剪切波速度（SWV）与乳腺癌病理分级及分型的关系。方法 回顾性分析70例经病理证实的乳腺癌患者，术前均接受常规超声及VTIQ检查，获得病灶剪切波速度（SWV），对比不同病理分级及分型病灶SWV，分析SWV与临床病理参数的关系。结果 70例乳腺癌患者共71个病灶，平均SWV为（6.30±1.87）m/s。SWV与Ki-67、人类表皮生长因子受体2（HER-2）表达及腋窝淋巴结转移有关（P均<0.05），与雌激素受体（ER）、孕激素受体（PR）表达无关（P均>0.05）。病灶SWV与其最大径呈正相关（r=0.372，P=0.001）。Ⅰ级（n=7）、Ⅱ级（n=31）、Ⅲ级（n=26）乳腺癌的SWV分别为（5.31±1.74）、（6.05±1.99）及（7.05±1.62）m/s，Ⅰ、Ⅱ级SWV均低于Ⅲ级（P均<0.05）。Luminal-A型（n=14）、Luminal-B型（n=41）、HER-2过表达型（n=10）及三阴性型（n=6）乳腺癌的SWV分别为（4.09±1.15）、（6.70±1.77）、（7.08±1.57）及（6.53±2.04）m/s，Luminal-B型、HER-2过表达型及三阴性型SWV均高于Luminal-A型（P均<0.05）。结论 VTIQ技术检测SWV有助于乳腺癌病理分级及分型。 |
| 英文摘要: |
| Objective To observe the relationships of shear wave velocity (SWV) obtained with virtual touch tissue imaging quantification (VTIQ) with pathological classification and typing of breast cancer. Methods Totally 70 patients with breast cancer confirmed by pathology were enrolled. Preoperative routine ultrasound and VTIQ examination were performed to obtain SWV of the lesions. SWV of lesions with different pathological classification and typing were compared, and the relationships of SWV with clinicopathological parameters were analyzed. Results There were 71 lesions in 70 breast cancer patients, the average SWV was(6.30±1.87)m/s. There were significant differences of SWV between the expressions of Ki-67, human epidermal growth factor receptor 2 (HER-2) and axillary lymph node metastasis (all P<0.05), but there was no significant difference of SWV between expression of estrogen receptor (ER) and progesterone receptor (PR) (both P>0.05). SWV was positively correlated with the maximum diameter of the lesions (r=0.372, P=0.001). SWV of grade Ⅰ (n=7), grade Ⅱ (n=31) and grade Ⅲ (n=26) lesions were (5.31±1.74), (6.05±1.99) and (7.05±1.62) m/s, respectively. The grade Ⅰ and Ⅱ lesions exhibited lower SWV than grade Ⅲ (both P<0.05). SWV of Luminal-A type (n=14), Luminal-B type (n=41), HER-2 overexpression type (n=10) and tri-negative type (n=6) lesion were (4.09±1.15), (6.70±1.77), (7.08±1.57) and (6.53±2.04) m/s, respectively. Luminal-B type, HER-2 overexpression type and tri-negative type lesions exhibited higher SWV than Luminal-A type (all P<0.05). Conclusion SWV obtained with VTIQ was helpful for pathological classification and typing of breast cancer. |
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