| 谭雪莹,张晶,任卫东,于佳慧.纵向分层应变评价乳腺癌新辅助化疗患者左心室收缩功能[J].中国医学影像技术,2021,37(6):880~884 |
| 纵向分层应变评价乳腺癌新辅助化疗患者左心室收缩功能 |
| Longitudinal layered strain in observation on left ventricular systolic function of breast cancer patients during neoadjuvant chemotherapy |
| 投稿时间：2020-04-03 修订日期：2021-04-02 |
| DOI：10.13929/j.issn.1003-3289.2021.06.021 |
| 中文关键词: 乳腺肿瘤 新辅助治疗 心房功能,左 超声心动描记术 二维斑点追踪成像 |
| 英文关键词:breast neoplasms neoadjuvant therapy ventricular function, left echocardiography two-dimensional speckle tracking imaging |
| 基金项目:国家自然科学基金青年项目（81801710）。 |
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| 中文摘要: |
| 目的 评价二维斑点追踪成像（2D-STI）技术纵向分层应变判断乳腺癌患者接受新辅助化疗（NACT）前后左心室收缩功能变化的价值。方法 纳入47例接受NACT的乳腺癌患者，对比其化疗前（T0）及每次化疗后（T1~T6）心肌肌钙蛋白Ⅰ（cTnⅠ）、心电图（ECG）、超声心动图及2D-STI参数的差异。结果 左心室射血分数（LVEF）于T4开始出现降低（P均<0.05），其余cTnⅠ、ECG及常规超声心动图参数T0~T6各时间点差异均无统计学意义（P均>0.05）；2D-STI各参数，包括左心室整体纵向应变（LVGLS）、心内膜下心肌（GLS-Endo）、中层（GLS-Mid）及外膜下（GLS-Epi）纵向应变参数均呈下降趋势，其中LVGLS及GLS-Endo于T1开始显著降低，GLS-Mid和GLS-Epi于T3始显著降低（P均<0.05）。结论 乳腺癌患者接受NACT期间左心室收缩功能均有不同程度受损；2D-STI技术可较准确地评价其左心室早期收缩功能改变，以GLS-Endo最为敏感。 |
| 英文摘要: |
| Objective To observe the value of two-dimensional speckle tracking imaging (2D-STI) longitudinal layered strain on assessment of left ventricular systolic function in breast cancer patients before and after neoadjuvant chemotherapy (NACT). Methods A total of 47 breast cancer patients who underwent NACT were enrolled. Parameters of cardiac troponin Ⅰ (cTnⅠ), electrocardiogram (ECG), echocardiography, as well as 2D-STI including left ventricular global longitudinal strain (LVGLS), global longitudinal strain in subendocardial myocardium (GLS-Endo), middle myocardium (GLS-Mid) and subepicardial myocardium (GLS-Epi)were compared before chemotherapy (T0) and after each time of chemotherapy (T1-T6). Results Besides of the left ventricular ejection fraction (LVEF) which significantly decreased at T4 (all P<0.05),there was no significant change of cTnⅠ, ECG nor the other echocardiographic parameters (all P>0.05). The longitudinal strain parameters showed decreasing trends, among which LVGLS and GLS-Endo decreased at T1, GLS-Mid and GLS-Epi decreased at T3 (all P<0.05). Conclusion Left ventricular systolic function in breast cancer patients was impaired during NACT. 2D-STI technique could accurately evaluate the changes of left ventricular early systolic function, and GLS-Endo was the most sensitive. |
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