| 刘瑜琳,章蓉,卢冬梅,岳丽娜,杨晓萍.乳腺癌全肿瘤体素内不相干运动-弥散加权成像(IVIM-DWI)直方图定量参数与ER、PR和HER-2表达的相关性[J].中国医学影像技术,2021,37(3):380~385 |
| 乳腺癌全肿瘤体素内不相干运动-弥散加权成像(IVIM-DWI)直方图定量参数与ER、PR和HER-2表达的相关性 |
| Correlations of whole volume intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) histogram quantitative parameters and ER, PR and HER-2 expression in breast cancer |
| 投稿时间：2020-02-19 修订日期：2020-11-09 |
| DOI：10.13929/j.issn.1003-3289.2021.03.017 |
| 中文关键词: 乳腺肿瘤 磁共振成像 体素内不相干运动 免疫组织化学 |
| 英文关键词:breast neoplasms magnetic resonance imaging intravoxel incoherent motion immunohistochemistry |
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| 中文摘要: |
| 目的 探讨乳腺癌全肿瘤体素内不相干运动弥散加权成像（IVIM-DWI）直方图定量参数与乳腺癌雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体-2（HER-2）表达的相关性。方法 回顾性分析56例经病理证实的乳腺癌患者（57个病灶）。比较ER、PR和HER-2阳性组与阴性组间真扩散系数（D）、假性扩散系数（D*）和灌注分数（f）的直方图参数，包括最小值（minimum）、最大值（maximum）、平均值（mean），第10、25、50、75、90百分位数（10th、25th、50th、75th、90th）及偏度（skewness）及峰度（kurtosis）的差异；分析各直方图参数与乳腺癌ER、PR和HER-2表达的相关性。结果 ER阳性组D值的mean、25th、50th、75th均高于ER阴性组；而D值的skewness及kurtosis，D*值的mean、maximum、75th、90th及f值的25th、90th均低于ER阴性组（P均<0.05）。PR阳性组D*值的minimum、10th、25th均高于PR阴性组，而D*值的mean、maximum、75th、90th均低于PR阴性组（P均<0.05）。HER-2阳性组D值的mean、minimum、10th、25th、50th及25th D*值均高于HER-2阴性组（P均<0.05）。D值的mean、25th、50th、75th与ER表达呈弱至中度正相关（r=0.29~0.36，P均<0.05），而D值的kurtosis和skewness、D*值的mean、maximum、75th、90th及25th、90th f值与ER表达呈弱至中度负相关（r=－0.26~－0.41，P均<0.05）；D*值的minimum、10th、25th与PR表达呈弱至强度正相关（r=0.27~0.50，P均<0.05），而D*值的mean、maximum、75th与PR表达呈中度至强度负相关（r=－0.31~－0.51，P均<0.05）；D值的mean、10th、25th、50th及25th D*值与HER-2表达呈弱至中度正相关（r=0.27~0.38，P均<0.05）。结论 IVIM-DWI直方图定量参数与乳腺癌ER、PR和HER-2表达存在不同程度相关性。 |
| 英文摘要: |
| Objective To explore the correlations of histogram quantitative parameters of whole volume intravoxel incoherent motion-diffusion weighted imaging (IVIM-DWI) and estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor-2 (HER-2) expression in breast cancer. Methods The pathologic and MRI IVIM-DWI data of 56 breast cancer patients (57 lesions) confirmed by pathology were analyzed retrospectively. The histogram parameters of true diffusion coefficient (D value), pseudo diffusion coefficient (D* value) and perfusion fraction (f value) were compared between ER, PR and HER-2 positive and negative groups, including the minimum, maximum, mean, 10th, 25th, 50th (median), 75th, 90th,skewness and kurtosis. The correlations of the histogram parameters and the expression of ER, PR and HER-2 of breast cancer were analyzed. Results The mean, 25th, 50th and 75th D values in ER positive group were higher than those in ER negative group, while the skewness and kurtosis of D values, the mean, maximum, 75th, 90th D* values, 25th and 90th f values were lower than those in ER negative group (all P<0.05). The minimum, 10th and 25th D* values in PR positive group were higher than those in PR negative group, while the mean, maximum, 75th and 90th D* values were lower than those in PR negative group (all P<0.05). The mean, minimum, 10th, 25th, 50th D values and 25th D* value in HER-2 positive group were higher than those in HER-2 negative group (all P<0.05). The mean, 25th, 50th, 75th D values showed weak to moderate positive correlations with ER expression (r=0.29-0.36, all P<0.05), while kurtosis and skewness of D values, the mean, maximum, 75th, 90th D* values and 25th, 90th f values showed weak to moderate negative correlations with ER expression (r=-0.26——0.41, all P<0.05), the minimum, 10th, 25th D* values showed weak to strong positive correlations with PR expression (r=0.27-0.50, all P<0.05). The mean, maximum, 75th D* values showed moderate to strong negative correlations with PR expression (r=-0.31-0.51, all P<0.05), and the mean, 10th, 25th, 50th D values and 25th D* value showed weak to moderate positive correlations with HER-2 expression (r=0.27-0.38, all P<0.05). Conclusion IVIM-DWI histogram quantitative parameters were correlated with the expression of ER, PR and HER-2 in breast cancer in varied degrees. |
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