| 刘帮燕,赵丽霞,郑曙光,牟爽,赵诚.超声多参数评分诊断慢性肾病[J].中国医学影像技术,2021,37(2):273~277 |
| 超声多参数评分诊断慢性肾病 |
| Ultrasound multi-parameter scoring in diagnosis of chronic kidney disease |
| 投稿时间：2019-10-11 修订日期：2021-02-07 |
| DOI：10.13929/j.issn.1003-3289.2021.02.025 |
| 中文关键词: 肾功能不全,慢性 肾小球滤过率 超声检查 |
| 英文关键词:renal insufficiency, chronic glomerular filtration rate ultrasonography |
| 基金项目:国家自然科学基金（81301229）、山东省自然科学基金青年项目（ZR2020QH269）。 |
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| 中文摘要: |
| 目的 探讨超声多参数评分诊断慢性肾病（CKD）的应用价值。方法 选取470例CKD患者，根据血肌酐值计算肾小球滤过率（e-GFR），并据以将其分为CKD 1~5期。采用超声测量肾脏长度、实质厚度、长轴面积、实质回声强度，对以上参数进行评分，并计算超声多参数评分，分析e-GFR与超声参数的相关性。以e-GFR<60 ml/（min·1.73 m2）作为标准CKD诊断，应用受试者工作特征（ROC）曲线评估超声多参数评分鉴别诊断CKD的准确率。结果 e-GFR与超声参数均显著相关（P均<0.01），与肾脏长度、实质厚度、长轴面积呈正相关（r=0.37、0.41、0.38，P均<0.01），与肾实质回声强度、超声多参数评分呈负相关（r=-0.53、-0.65，P均<0.01）。ROC曲线分析发现，截断值取9.50时，CKD超声多参数评分鉴别诊断CKD的曲线下面积（AUC）为0.84（P<0.01）。结论 超声多参数评分诊断CKD准确率较高，具有一定临床价值。 |
| 英文摘要: |
| Objective To explore the value of ultrasound multi-parameter scoring for diagnosis of chronic kidney disease (CKD). Methods A total of 470 patients with CKD were divided into CKD 1-5 stages according to calculating glomerular filtration rate (e-GFR) on the basis of serum creatinine. The kidney length, parenchymal thickness, long axis area and parenchymal echogenicity were measured with ultrasound, and all the parameters were scored for ultrasound multi-parameter scoring. The correlations of e-GFR and ultrasonic parameters were analyzed, while e-GFR<60 ml/(min·1.73 m2) was taken as the diagnostic criteria of CKD, and the accuracy of ultrasound multi-parameter scoring for differential diagnosis of CKD was evaluated with receiver operating characteristic (ROC) curve. Results e-GFR was significantly correlated with ultrasonic parameters (all P<0.01), which was positively correlated with renal length, parenchymal thickness and the long axis area (r=0.37, 0.41, 0.38; all P<0.01),but negatively correlated with parenchymal echogenicity and ultrasound multi-parameter scoring (r=-0.53, -0.65, both P<0.01). Based on ROC curve analysis, taken the optional cut-off value of ultrasound multi-parameter scoring as 9.50, the area under the curve (AUC) of differential diagnosis of CKD was 0.84 (P<0.01). Conclusion Ultrasound multi-parameter scoring was of high accuracy for diagnosis of CKD, therefore having good clinical value. |
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