| 丁雅玲,曹代荣,马小敏,张杰,黄新发,陈春华.弥散加权成像鉴别诊断儿童良恶性肝肿瘤[J].中国医学影像技术,2021,37(2):250~253 |
| 弥散加权成像鉴别诊断儿童良恶性肝肿瘤 |
| Diffusion weighted imaging in differential diagnosis of benign and malignant liver tumors in children |
| 投稿时间：2020-04-02 修订日期：2021-01-31 |
| DOI：10.13929/j.issn.1003-3289.2021.02.020 |
| 中文关键词: 肝肿瘤 弥散磁共振成像 儿童 |
| 英文关键词:liver neoplasms diffusion magnetic resonance imaging child |
| 基金项目: |
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| 中文摘要: |
| 目的 观察弥散加权成像（DWI）鉴别诊断儿童良恶性肝肿瘤的价值。方法 回顾性分析32例肝肿瘤患儿资料，经病理和影像征象确诊良性（良性组）、恶性（恶性组）各16例，观察并比较2组肿瘤DWI信号特征、最大ADC值（ADCmax）、最小ADC值（ADCmin）和平均ADC值（ADCave）；采用受试者工作特征（ROC）曲线分析ADC值鉴别诊断儿童肝脏良恶性肿瘤的效能。结果 良性组8例病灶DWI呈T2穿透效应，2例弥散增加，6例中等弥散；恶性组13例病灶DWI呈弥散受限，2例T2穿透效应，1例中等弥散。恶性组81.25%（13/16） DWI呈弥散受限，显著高于良性组（0）（P<0.001）。恶性组肿瘤ADCmax、ADCmin和ADCave均小于良性组（P均<0.05）。ROC曲线结果显示，ADCmax、ADCmin、ADCave均可用于鉴别儿童良恶性肝肿瘤（P均<0.05），ADCmin阈值为1.31×10-3 mm2/s时，其鉴别儿童良恶性肝肿瘤的曲线下面积（AUC）最大（0.941）。结论 DWI有助于鉴别诊断儿童良恶性肝肿瘤。 |
| 英文摘要: |
| Objective To investigate the value of diffusion weighted imaging (DWI) in differential diagnosis of benign and malignant liver tumors in children. Methods MRI data of 32 children with liver tumors, including 16 benign tumors (benign group) and 16 malignant tumors (malignant group) confirmed by pathology and imaging signs were retrospectively analyzed. The characteristics of DWI signals were observed and compared, and the maximum ADC value (ADCmax), minimum ADC value (ADCmin), and average ADC value (ADCave) were measured and compared between groups. ROC curve was used to analyze ADC value for differential diagnosis of benign and malignant liver tumors in children. Results In benign group, DWI showed T2 shine-through in 8 cases, with increased diffusion in 2 cases and intermediate diffusion in 6 cases. In malignant group, 13 cases were found with diffusion restriction on DWI, 2 cases with T2 shine-through and 1 case of intermediate diffusion. The proportion of diffusion restriction on DWI in malignant group was 81.25% (13/16), significantly higher than that in the benign group (P<0.001). ADCmax, ADCmin and ADCave of malignant group were all lower than those of benign group (all P<0.05). The results of ROC curve showed that ADCmax, ADCmin and ADCave could be used to distinguish benign and malignant liver tumors in children (all P<0.05). Taken 1.31×10-3 mm2/s as the threshold of ADCmin, the area under the curve (AUC) of differentiating benign and malignant liver tumors in children was the largest (0.941). Conclusion DWI was helpful to differential diagnosis of benign and malignant liver tumors in children. |
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