| 吴骥,范敏,江国豪,欧蕾,龚维冬,吴俊豪,张春银.18F-FDG PET/CT联合血清神经元特异性烯醇化酶及胃泌素释放肽前体诊断小细胞肺癌[J].中国医学影像技术,2021,37(2):235~239 |
| 18F-FDG PET/CT联合血清神经元特异性烯醇化酶及胃泌素释放肽前体诊断小细胞肺癌 |
| 18F-FDG PET/CT combined with serum neuron-specific enolase and pro-gastrin-releasing peptide for diagnosing small cell lung cancer |
| 投稿时间：2020-09-29 修订日期：2021-01-29 |
| DOI：10.13929/j.issn.1003-3289.2021.02.016 |
| 中文关键词: 小细胞肺癌 生物标志物,肿瘤 正电子发射断层显像 18F氟脱氧葡萄糖 |
| 英文关键词:small cell lung carcinoma biomarkers, tumor positron-emission tomography fluorodeoxyglucose F18 |
| 基金项目: |
|
| 摘要点击次数: 2552 |
| 全文下载次数: 938 |
| 中文摘要: |
| 目的 评价18F-FDG PET/CT显像联合血清神经元特异性烯醇化酶（NSE）及胃泌素释放肽前体（Pro-GRP）对小细胞肺癌（SCLC）的诊断价值。方法 回顾性分析80例接受18F-FDG PET/CT、血清NSE及Pro-GRP检测的肺占位患者，根据病理及随访结果分为SCLC组（n=40）和良性病变组（n=40）；计算18F-FDG PET/CT联合肿瘤标志物诊断SCLC的敏感度、特异度、准确率、阳性预测值及阴性预测值，绘制受试者工作特征（ROC）曲线，评价不同指标诊断SCLC的效能。结果 18F-FDG PET/CT联合肿瘤标志物诊断SCLC的敏感度、特异度、准确率、阳性预测值及阴性预测值分别是95.00%、100%、97.50%、100%及95.24%。NSE、Pro-GRP、Pro-GRP+NSE以及三项联合诊断SCLC的曲线下面积（AUC）分别为0.86、0.88、0.96和0.98。结论 18F-FDG PET/CT显像联合血清NSE+PRo-GRP检测可提高诊断SCLC的敏感度和特异度，对早期诊断、分期及治疗具有指导意义。 |
| 英文摘要: |
| Objective To observe the value of 18F-FDG PET/CT combined with serum neuron-specific enolase (NSE) and pro-gastrin-releasing peptide (Pro-GRP) in diagnosis of small cell lung cancer (SCLC). Methods Data of 18F-FDG PET/CT, NSE and Pro-GRP of 80 patients with pulmonary occupying lesion were retrospectively analyzed. The patients were divided into SCLC group (n=40) and benign disease group (n=40) according to pathological and follow-up results. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18F-FDG PET/CT combined with tumor markers for diagnosing SCLC were calculated, and receiver operating characteristic (ROC) curves were drawn to evaluate the efficacy of different indicators for diagnosis of SCLC. Results The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18F-FDG PET/CT combined with tumor markers for diagnosing SCLC was 95.00%, 100%, 97.50%, 100% and 95.24%, respectively. The area under the curve (AUC) of NSE, Pro-GRP, Pro-GRP+NSE and 18F-FDG PET/CT+Pro-GRP+NSE for diagnosis of SCLC were 0.86, 0.88, 0.96 and 0.98, respectively. Conclusion 18F-FDG PET/CT combined with serum NSE+Pro-GRP detection could improve the sensitivity and specificity for diagnosis of SCLC, having significances for early diagnosis, staging and guiding treatment of SCLC. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
