| 王晓,胡晓,刘海燕,黄清玲,柴学,李宗鸿,胡君,肖朝勇.磁共振波谱分析海马诊断首发抑郁症[J].中国医学影像技术,2021,37(2):189~193 |
| 磁共振波谱分析海马诊断首发抑郁症 |
| Magnetic resonance spectroscopy in hippocampus for diagnosis of first-episode depression disorder |
| 投稿时间：2020-07-08 修订日期：2020-12-22 |
| DOI：10.13929/j.issn.1003-3289.2021.02.007 |
| 中文关键词: 抑郁症 磁共振波谱学 海马 |
| 英文关键词:depressive disorder magnetic resonance spectroscopy hippocampus |
| 基金项目:国家自然科学基金青年科学基金（81701671）、南京市医学科技发展项目（YKK11032）。 |
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| 中文摘要: |
| 目的 观察磁共振波谱分析（MRS）所示双侧海马代谢物改变对于诊断首发抑郁症（DD）的意义。方法 对44例首发DD患者（DD组）及20名正常人（对照组）测量双侧海马肌酸（Cr）、N-乙酰天门冬氨酸（NAA）、胆碱（Cho）和肌醇（MI）峰下面积，计算NAA/Cr、Cho/Cr及MI/Cr，分析组间各指标差异；采用Logistic回归建立预测模型，以ROC曲线计算相关代谢物改变，作为首发DD临床诊断指标，并基于约登指数得出诊断阈值。结果 DD组右侧海马Cho、NAA/Cr、Cho/Cr值均低于对照组（P均<0.05），右侧海马NAA、Cho、NAA/Cr、Cho/Cr和预测模型诊断DD的敏感度分别为54.54%、50.00%、45.45%、63.63%和77.27%，特异度分别为90.00%、100%、100%、80.00%和80.00%。结论 MRS可辅助诊断首发DD；海马区Cho及Cho/Cr下降可能是早期DD标志，Cho、NAA/Cr及Cho/Cr可作为诊断首发DD的指标。 |
| 英文摘要: |
| Objective To observe the value of hippocampal metabolite changes detected with magnetic resonance spectroscopy (MRS) for diagnosis of first-episode depression disorder (DD).Methods Creatine (Cr), N-acetylaspartate (NAA), choline (Cho) and inositol (MI) peak area in bilateral hippocampus were measured in 44 patients with first-episode DD (DD group) and 20 normal subjects (control group). The ratio of NAA/Cr, Cho/Cr and MI/Cr were calculated, and the indexes were compared between 2 groups. Then prediction model was established using Logistic regression, and the changes of related metabolites were calculated with ROC curve and taken as the clinical diagnostic indexes of first-episode DD, while the diagnosis threshold was given based on Youden index.Results Cho, NAA/Cr, Cho/Cr in right hippocampus of DD group were all significantly higher than those in control group (all P<0.05), the sensitivity of Cho, NAA/Cr, Cho/Cr in right hippocampus and prediction model for diagnosis of DD was 54.54%, 50.00%, 45.45%, 63.63% and 77.27%, the specificity was 90.00%, 100%, 100%, 80.00% and 80.00%, respectively.Conclusion MRS might assist diagnosis of first-episode DD.The decrease of Cho and Cho/Cr in hippocampus might be signs of DD, while Cho, NAA/Cr and Cho/Cr could be used as diagnostic markers. |
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