| 黄静文,黎继昕,苏赟,梁碧玲,杨绮华.MR T1rho成像诊断肝硬化及其与肝功能Child-Pugh分级的关系[J].中国医学影像技术,2021,37(1):81~85 |
| MR T1rho成像诊断肝硬化及其与肝功能Child-Pugh分级的关系 |
| MR T1rho imaging in diagnosis of liver cirrhosis and relationship with Child-Pugh classification of liver function |
| 投稿时间：2019-11-02 修订日期：2020-05-12 |
| DOI：10.13929/j.issn.1003-3289.2021.01.019 |
| 中文关键词: 肝硬化 诊断 磁共振成像 |
| 英文关键词:liver cirrhosis diagnosis magnetic resonance imaging |
| 基金项目:广东省自然科学基金（2018A0303130099）、中山大学临床医学研究5010计划（2013004）。 |
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| 中文摘要: |
| 目的 观察MR T1rho成像诊断肝硬化的可行性，分析其与Child-Pugh肝功能分级的关系。方法 对42例肝硬化患者和22名健康成年志愿者行肝脏MR T1rho检查，对比T1rho值与Child-Pugh肝功能分级，拟合T1rho值诊断肝硬化的ROC曲线。结果 Child-Pugh A、B、C级组肝T1rho值分别为（46.32±3.80） ms、（48.08±3.97） ms、（54.43±2.48） ms，均高于健康志愿者（41.45±2.51） ms （P均<0.01）。Child-Pugh A与C级、B与C级T1rho值差异均有统计学意义（P均<0.01），而A与B级T1rho值差异无统计学意义（P=0.17）。Child-Pugh分级与T1rho值呈正相关（r=0.81，P<0.01），根据肝T1rho值鉴别不同Child-Pugh分级肝硬化的AUC为0.82~0.95（P均<0.01）。结论 MR T1rho成像可用于定量诊断肝硬化，并可初步评价肝硬化患者Child-Pugh肝功能分级。 |
| 英文摘要: |
| Objective To observe the feasibility of MR T1rho imaging in diagnosis of liver cirrhosis, and to analyze the relationship between T1rho value and Child-Pugh liver function classification. Methods Totally 42 patients with liver cirrhosis and 22 healthy volunteers underwent liver MR T1rho imaging. T1rho values were compared with Child-Pugh classification. ROC curves were calculated to evaluate the accuracy of T1rho values for assessment of different Child-Pugh classification. Results T1rho values of patients with Child-Pugh class A, B, C was (46.3±3.80) ms, (48.08±3.97) ms and (54.43±2.48) ms, respectively, all higher than that of volunteers (ms). There were significant differences of T1rho values between Child-Pugh class A and C (P<0.01) as well as between B and C (P<0.01), but not between class A and C (P=0.17). There was positive correlation between Child-Pugh classification and T1rho values (r=0.81, P<0.01). AUC of T1rho values in differentiating liver cirrhosis with different Child-Pugh grades were 0.84-0.95. Conclusion MR T1rho imaging was feasible to detect human liver cirrhosis, which might be used to Differentiate liver cirrhosis patients with different Child-Pugh grades. |
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