| 侯芬,李恒国,李平,周智凤,刘霞.基于度中心度和种子点功能连接观察早盲青少年静息态功能fMRI改变[J].中国医学影像技术,2021,37(1):26~29 |
| 基于度中心度和种子点功能连接观察早盲青少年静息态功能fMRI改变 |
| Observation on changes of resting-state functional MRI in early blind adolescents based on degree centrality and seed-based functional connectivity |
| 投稿时间：2019-11-17 修订日期：2020-07-09 |
| DOI：10.13929/j.issn.1003-3289.2021.01.005 |
| 中文关键词: 度中心度 功能连接 盲 青少年 磁共振成像 |
| 英文关键词:degree centrality functional connectivity blindness adolescent magnetic resonance imaging |
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| 中文摘要: |
| 目的 基于体素度中心度（DC），结合种子点功能连接（SFC）方法，以静息态功能MRI （rs-fMRI）观察早盲青少年静息态下脑功能连接异常改变。方法 对16例早盲青少年（观察组）和性别及年龄相匹配的16名正常视力志愿者（对照组）采集rs-fMRI数据，比较2组DC值差异；以组间DC值存在显著差异的脑区作为ROI，采用SFC方法计算其与其他脑区间的功能连接。结果 观察组初级视觉皮层（右侧距状沟、双侧舌回） DC值较对照组降低，而语言皮层（双侧三角部额下回、右侧岛叶） DC值较对照组升高（P均<0.05）。观察组与右侧距状沟功能连接减低脑区包括初级视觉皮层（左侧距状沟、双侧舌回）和非视觉皮层（双侧中央后回、楔前叶、顶上小叶、中央旁小叶、额中回、颞上回及颞中回）。结论 早盲患者脑网络功能连接存在异常改变，与失用性萎缩和功能重塑相关。联合DC和SFC分析方法可为研究盲人脑网络改变及病理生理机制提供更宽阔的视角。 |
| 英文摘要: |
| Objective To observe the abnormal changes of brain functional connectivity in early blind adolescents using resting-state functional MRI (rs-fMRI) based on degree centrality (DC) and seed-based functional connectivity (SFC) methods by. Methods Totally 16 early blind adolescents (observation group) and 16 age- and gender-matched sighted volunteers (control group) were recruited. rs-fMRI data were collected, and DC values were compared between groups. Taken brain regions with significant differences of DC values between groups as ROI, their functional connections with other brain regions were calculated using SFC method. Results DC values of primary visual cortex (right calcarine sulcus and bilateral lingual gyrus) in observation group were lower than those in control group, while of the language cortices (bilateral triangular part of inferior frontal gyrus and right insular lobe) in observation group were higher than those in the control group (all P<0.05). The primary visual cortex (left calcarine sulcus and bilateral lingual gyrus) and non-visual cortex (bilateral postcentral gyrus, precuneus, superior parietal lobule, paracentral lobule, middle frontal gyrus, superior temporal gyrus and middle temporal gyrus) showed decreased functional connections to the right talar sulcus in observation group. Conclusion Abnormal changes in brain network function connections in early blind adolescents related to atrophy and reshaping. Combination of DC and SFC may provide a comprehensive view for brain functional networks and pathophysiology of blindness. |
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