| 俞顺,吕洁勤,马明平,苏家威.MR Dixon技术定量分析胰腺脂肪沉积及其对2型糖尿病的影响[J].中国医学影像技术,2020,36(12):1891~1895 |
| MR Dixon技术定量分析胰腺脂肪沉积及其对2型糖尿病的影响 |
| MR Dixon technique in quantify of pancreatic fat deposition and the relative impact on type 2 diabetes mellitus |
| 投稿时间：2019-11-12 修订日期：2020-07-20 |
| DOI：10.13929/j.issn.1003-3289.2020.12.028 |
| 中文关键词: 糖尿病,2型 胰腺 脂肪组织 磁共振成像 |
| 英文关键词:diabetes mellitus, type 2 pancreas adipose tissue magnetic resonance imaging |
| 基金项目:福建省自然科学基金（2017J01172）、中华国际医学交流基金会SKY影像科研基金发展项目（z-2014-07-1912-14）。 |
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| 中文摘要: |
| 目的 应用MR Dixon技术定量胰腺脂肪沉积，观察胰腺脂肪含量对2型糖尿病（T2DM）的影响。方法 对118例T2DM患者（T2DM组）及39名健康志愿者（NC组）采集腹部MR Dixon序列图像，获得胰头、胰颈、胰体、胰尾脂肪分数、胰腺平均脂肪分数、腹壁皮下脂肪面积（SA）及腹腔内脏脂肪面积（VA），计算腹部总脂肪面积（TA）。以体质量指数（BMI）≥25 kg/m2为肥胖标准，根据是否肥胖将2组细分为NT2DM亚组、OT2DM亚组和NNC亚组、ONC亚组，比较各参数差异。结果 NT2DM亚组64例，OT2DM亚组54例；NNC亚组28名，ONC亚组11名。NT2DM亚组胰腺平均脂肪分数、胰体脂肪分数、胰尾脂肪分数、VA均高于NNC亚组（P均<0.05）。OT2DM亚组胰腺平均脂肪分数、胰头脂肪分数、VA均高于ONC亚组（P均<0.05）。OT2DM亚组胰腺平均脂肪分数、胰体脂肪分数、胰尾脂肪分数、SA、VA及TA均高于NT2DM亚组（P均<0.05）。对非肥胖者，空腹血糖（FBG）、甘油三酯、胰体脂肪分数、胰尾脂肪分数、胰腺平均脂肪分数及VA均为T2DM的危险因素（P均<0.05）；而对于肥胖者，FBG、VA为T2DM的危险因素（P均<0.05）。结论 MR Dixon技术可用于无创测量胰腺脂肪含量；无论是否肥胖，胰腺脂肪沉积均为发生T2DM的危险因素。 |
| 英文摘要: |
| Objective To quantitatively analyze pancreatic fat deposition using MR Dixon technique,and to investigate the impact of pancreatic fat on type 2 diabetes mellitus (T2DM). Methods Totally 118 T2DM patients (T2DM group) and 39 healthy controls (NC group) who underwent abdominal MR Dixon sequence scanning were enrolled. The fat fraction of pancreatic head, neck, body and tail, the mean pancreatic fat fraction, subcutaneous adipose area (SA), visceral adipose area (VA) were obtained, and total abdominal fat area (TA) was calculated. Taken body mass index (BMI) ≥25 kg/m2 as standard of obesity, the patients in 2 groups were further divided into OT2DM and NT2DM subgroups, while subjects in NC group were further divided into ONC and NNC subgroups. The above parameters were compared between groups and subgroups, respectively. Results There were 64 and 54 cases in NT2DM and OT2DM subgroup, 28 and 11 subjects in NNC and ONC subgroup, respectively. The mean pancreatic fat fraction, pancreatic body fat fraction, pancreatic tail fat fraction and VA in NT2DM subgroup were higher than those in NNC subgroup (all P<0.05). The mean pancreatic fat fraction, pancreatic head fat fraction and VA in OT2DM subgroup were higher than those in ONC subgroup (all P<0.05). The mean pancreatic fat fraction, pancreatic body fat fraction, pancreatic tail fat fraction, SA, VA, TA in OT2DM subgroup were all higher than those in NT2DM subgroup (all P<0.05). For non-obese ones, fasting blood glucose (FBG), triglyceride, pancreatic body fat fraction, pancreatic tail fat fraction, average pancreatic fat fraction and VA were risk factors for T2DM (all P<0.05), while for obese ones, FBG and VA were risk factors for T2DM (both P<0.05). Conclusion MR Dixon technology could be used to noninvasively evaluate pancreatic fat content. Pancreatic fat deposition was risk factor for T2DM regardless of obesity. |
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