| 张冉,肖新兰,钱斌燕.动脉自旋标记成像用于平扫MR阴性发作间期癫痫患儿[J].中国医学影像技术,2020,36(12):1776~1780 |
| 动脉自旋标记成像用于平扫MR阴性发作间期癫痫患儿 |
| Arterial spin labeling imaging in interictal epilepsy children with negative plain MR results |
| 投稿时间：2019-12-06 修订日期：2020-09-20 |
| DOI：10.13929/j.issn.1003-3289.2020.12.004 |
| 中文关键词: 癫痫 儿童 磁共振成像 动脉自旋标记 |
| 英文关键词:epilepsy child magnetic resonance imaging arterial spin labeling |
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| 中文摘要: |
| 目的 观察动脉自旋标记（ASL）成像对平扫MR阴性的发作间期癫痫患儿的诊断价值。方法 纳入56例平扫MR未显示结构异常的发作间期癫痫患儿，采用视觉分析法将ASL显示灌注异常分为低灌注或高灌注，与临床及视频脑电图（VEEG）定位癫痫灶结果进行一致性检验，并分析ASL异常灌注的影响因素。结果 56例中，52例（52/56，92.86%）为癫痫局灶性发作，4例（4/56，7.14%）为全身性发作。39例（39/56，69.64%）ASL显示灌注异常，37例（37/52，71.15%）为局灶性发作、2例（2/4，50.00%）为全身性发作；其中20例（20/39，51.28%）ASL显示灌注异常定位与临床定位癫痫灶完全一致，9例（9/39，23.08%）部分一致；ASL定位癫痫灶与临床定位结果具有中等一致性（Kappa=0.46，P<0.01）。于发作1天内行ASL是唯一与MR和临床定位癫痫灶一致性相关的因素（P<0.05）[OR=3.81，95% CI（1.16，12.44），P=0.027]。结论 ASL技术可于发作间期有效定位平扫MR阴性癫痫患儿的癫痫灶。 |
| 英文摘要: |
| Objective To observe the value of arterial spin labeling (ASL) in children with interictal epilepsy with negative plain MR results. Methods A total of 56 interictal epileptic children with negative plain MR results were included. ASL abnormalities were classified into hypo/hyperperfusion based on visual assessment and compared with the seizure focus determined by clinical data and video-electroencephalography (VEEG). The impact factors of abnormal ASL perfusion were analyzed. Results Among 56 cases, 52 (52/56, 92.86%) had focal seizures and 4 (4/56, 7.14%) had generalized seizures. Abnormal perfusion changes were found in 39 cases (39/56, 69.64%),including 37 cases (37/52, 71.15%) of focal seizures and 2 cases (2/4, 50.00%) of generalized seizures, among them 20 (20/39, 51.28%) ASL findings were completely consistent and 9 (9/39, 23.08%) were partially consistent with clinical localization of epileptic foci. ASL localization of epileptic foci was moderately consistent with clinical localization (Kappa=0.46, P<0.01). ASL acquired within 1 day after seizure was the only factor significantly associated with the consistency of ASL and clinical localization of epileptic foci (OR=3.81, 95% CI[1.16, 12.44], P=0.027). Conclusion ASL technique could effectively locate interictal epileptic foci in children with negative plain MR results. |
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