| 陈洋,张艳,闫志华,杨琦华,于瑞娜.超声造影与18F-FDG PET/CT判断多发性大动脉炎活动性的相关性[J].中国医学影像技术,2020,36(10):1470~1474 |
| 超声造影与18F-FDG PET/CT判断多发性大动脉炎活动性的相关性 |
| Correlation between contrast-enhanced ultrasound and 18F-FDG PET/CT for judging activity of Takayasu arteritis |
| 投稿时间：2019-08-11 修订日期：2020-01-08 |
| DOI：10.13929/j.issn.1003-3289.2020.10.007 |
| 中文关键词: 大动脉炎 氟脱氧葡萄糖F18 超声检查,介入性 正电子发射断层显像 |
| 英文关键词:Takayasu arteritis fluorodeoxyglucose F18 ultrasonography, interventional positron-emission tomography |
| 基金项目:河南省科技厅社会发展攻关项目（172102310048）。 |
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| 中文摘要: |
| 目的 探讨超声造影（CEUS）和18F-FDG PET/CT在多发性大动脉炎（TA）活动性判断中的相关性。方法 收集TA患者36例，均接受CEUS及18F-FDG PET/CT检查，比较相关实验室指标及影像学参数，分析CEUS与18F-FDG PET/CT评价TA活动性结果之间的相关性。结果 CEUS明显增强组在病程、印度大动脉炎临床活动性评分（ITAS 2010）、颈动脉闭塞比、CEUS峰值强度、PET/CT视觉评分及最大标准摄取值（SUVmax）与对照组间差异存在统计学意义（P均<0.05）；CEUS分级标准与PET/CT视觉评分呈中度相关（r=0.697，P<0.001），与临床活动性NIH标准及SUVmax均呈低度相关性（r=0.385，P=0.018；r=0.477，P=0.014）；以18F-FDG PET/CT视觉评分作为判断TA活动性的标准，临床活动性NIH标准的敏感度和特异度分别为0.783及0.769，CEUS的敏感度和特异度分别为1.000及0.846，AUC分别为0.776和0.923。结论 CEUS判断TA活动性与18F-FDG PET/CT存在明显正相关；以18F-FDG PET/CT视觉评分作为TA活动性的判断标准，CEUS较临床活动性标准具有更高的敏感度和特异度，可作为判断TA活动性的有效指标。 |
| 英文摘要: |
| Objective To explore the correlation between contrast-enhanced ultrasound (CEUS) and 18F-FDG PET/CT for judging activity of Takayasu arteritis (TA). Methods A total of 36 TA patients who underwent CEUS and 18F-FDG PET/CT were enrolled, the related laboratory indexes and imaging parameters were compared. The correlation between CEUS and 18F-FDG PET/CT for judging TA activity was analyzed. Results There were significant differences of disease duration, Indian Takayasu arteritis clinical activity score (ITAS 2010), carotid occlusion ratio, CEUS peak intensity, PET/CT uptake and the maximal standardized uptake value (SUVmax) between CEUS significantly enhanced group and non-enhanced or little enhanced group (all P<0.05). CEUS was moderately correlated with PET/CT visual score (r=0.697, P<0.001) and slightly correlated with NIH criteria of clinical activity and SUVmax (r=0.385, P=0.018; r=0.477, P=0.014). Taken 18F-FDG PET/CT visual score as the criterion of TA activity, the sensitivity and specificity of NIH criteria of clinical activity was 0.783 and 0.769, of CEUS was 1.000 and 0.846, and AUC was 0.776 and 0.923, respectively. Conclusion Significant positive correlation existed between CEUS and 18F-FDG PET/CT for judging TA activity. Taken18F-FDG PET/CT visual scoring as the standard, CEUS had higher sensitivity and specificity than clinical disease activity criteria, and might be used as an effective method for judging TA activity. |
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