| 邱明娟,席芊.动脉自旋标记成像用于轻度认知障碍研究进展[J].中国医学影像技术,2020,36(7):1093~1096 |
| 动脉自旋标记成像用于轻度认知障碍研究进展 |
| Research progresses of arterial spin labeling imaging in mild cognitive impairment |
| 投稿时间：2019-07-13 修订日期：2020-02-25 |
| DOI：10.13929/j.issn.1003-3289.2020.07.039 |
| 中文关键词: 轻度认知障碍 磁共振成像 局部脑血流量 |
| 英文关键词:mild cognitive impairment magnetic resonance imaging regional cerebral blood flow |
| 基金项目:国家自然科学基金（81301200）、上海市卫生和计划生育委员会科研项目（201740207）、上海市浦东新区卫生系统学科带头人培养计划项目（PWRd2016-07）。 |
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| 中文摘要: |
| 轻度认知障碍（MCI）是阿尔茨海默病（AD）的前驱期，对其发病机制尚不明确。脑血流量是衡量脑功能的重要指标，各种原因致局部脑血流量（rCBF）减低而损伤大脑。动脉自旋标记（ASL）MRI是通过磁化标记动脉血中氢质子作为内源性示踪剂测量rCBF的成像技术。本研究针对ASL成像在早期诊断MCI、监测疾病进展及评估疗效中的研究进展进行综述。 |
| 英文摘要: |
| Mild cognitive impairment (MCI) is a prodromal stage of Alzheimer's disease (AD), the pathogenesis of AD is still unclear. Cerebral blood flow is an important indicator of brain function. Various causes lead to decreased regional cerebral blood flow (rCBF) and damage brain. Arterial spin labeling (ASL) MRI is an imaging technology that measure rCBF by magnetizing hydrogen protons in labeled arterial blood as endogenous tracers. The progresses of ASL imaging in early diagnosis and monitoring progression as well as evaluation on therapeutic effects of MCI were reviewed in this article. |
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