| 刘亚超,刘家金,张晓军,王旻姝,董彦良,殷小涛,施彦坤,周晖,徐白萱,高江平.18F-DCFPyL PET/CT术前诊断前列腺癌区域转移淋巴结[J].中国医学影像技术,2020,36(6):868~872 |
| 18F-DCFPyL PET/CT术前诊断前列腺癌区域转移淋巴结 |
| 18F-DCFPyL PET/CT in pre-operative diagnosis of regional lymph node metastasis from prostate cancer |
| 投稿时间：2019-08-20 修订日期：2020-05-30 |
| DOI：10.13929/j.issn.1003-3289.2020.06.015 |
| 中文关键词: 前列腺肿瘤 体层摄影术,X线计算机 正电子发射断层显像 前列腺切除术 淋巴结切除术 |
| 英文关键词:prostatic neoplasms tomography, X-ray computed positron-emission tomography prostatectomy lymph node excision |
| 基金项目:国家自然科学基金面上项目（81571715）。 |
| 作者 | 单位 | E-mail | | 刘亚超 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 刘家金 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 张晓军 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 王旻姝 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 董彦良 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 殷小涛 | 中国人民解放军总医院泌尿外科, 北京 100853 | | | 施彦坤 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 周晖 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | | | 徐白萱 | 中国人民解放军总医院第一医学中心核医学科, 北京 100853 | xbx301@163.com | | 高江平 | 中国人民解放军总医院泌尿外科, 北京 100853 | |
|
| 摘要点击次数: 3226 |
| 全文下载次数: 701 |
| 中文摘要: |
| 目的 观察18F-DCFPyL PET/CT显像术前诊断前列腺癌区域淋巴结转移的价值。方法 回顾性分析49例同时接受前列腺根治性切除术及盆腔淋巴结清扫术的前列腺癌患者的术前18F-DCFPyL PET/CT图像及其临床资料，统计术中清扫淋巴结总数及转移淋巴结情况，计算18F-DCFPyL PET/CT对区域转移淋巴结的诊断效能，比较切除后转移淋巴结与非转移淋巴结的长径、中径及短径。结果 49例共清扫511枚淋巴结，其中10例共14枚淋巴结转移，18F-DCFPyL PET/CT正确诊断出其中9例共12枚转移淋巴结。18F-DCFPyL PET/CT术前诊断前列腺癌区域淋巴结转移的灵敏度为90.00%，特异度为100%，准确率为97.96%，阳性预测值为100%，阴性预测值为97.50%。切除后转移淋巴结与非转移淋巴结的长径均值为（1.64±0.33）cm和（1.12±0.79）cm，中径（1.05±0.23 cm）和（0.59±0.51）cm，短径（0.61±0.14）cm和（0.36±0.24）cm，差异均无统计学意义（P均>0.05）。结论 18F-DCFPyL PET/CT对前列腺癌区域淋巴结转移具有较高诊断价值。 |
| 英文摘要: |
| Objective To explore the value of 18F-DCFPyL PET/CT in pre-operative diagnosis of regional lymph node metastasis in patients with prostate cancer. Methods Preoperative 18F-DCFPyL PET/CT images and clinical data of 49 patients with prostate cancer who underwent radical prostatectomy and pelvic lymph node dissection simultaneously were retrospectively analyzed. The total number of dissected lymph nodes and metastatic lymph nodes were counted, and the diagnostic efficacy of 18F-DCFPyL PET/CT for regional metastatic lymph nodes was calculated. The differences of the long diameter, middle diameter and short diameter of metastatic lymph nodes and non-metastatic lymph nodes were compared after resection. Results A total of 511 lymph nodes were dissected in 49 patients. Fourteen lymph node metastases were found in 10 patients, 9 of which were correctly diagnosed by 18F-DCFPyL PET/CT. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of 18F-DCFPyL PET/CT in diagnosis of lymph node metastasis of prostate cancer was 90.00%, 100%, 97.96%,100% and 97.50%, respectively. The mean long diameter, medium diameter and short diameter of metastatic lymph nodes and non-metastatic lymph nodes were (1.64±0.33)cm and (1.12±0.79)cm, (1.05±0.23)cm and (0.59±0.51)cm, (0.61±0.14)cm and (0.36±0.24)cm after resection (all P>0.05). Conclusion Regional lymph node metastasis of prostate cancer is independent of its size. 18F-DCFPyL PET/CT has high diagnostic value for pre-operative diagnosis of regional lymph node metastasis in patients with prostate cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
