| 王荣甲,任克,王永芳.体素内不相干运动扩散成像及血氧水平依赖成像评估碘对比剂致兔急性肾损伤[J].中国医学影像技术,2020,36(5):641~647 |
| 体素内不相干运动扩散成像及血氧水平依赖成像评估碘对比剂致兔急性肾损伤 |
| Acute kidney injury induced by iodine contrast agent in a rabbit model using intravoxel incoherent motion and blood oxygen level-dependent imaging techniques |
| 投稿时间：2019-09-21 修订日期：2019-12-22 |
| DOI：10.13929/j.issn.1003-3289.2020.05.001 |
| 中文关键词: 急性肾损伤 造影剂 碘 血氧水平依赖 体素内不相干运动成像 兔 |
| 英文关键词:acute kidney injury contrast media iodine blood oxygenation level-dependent intravoxel incoherent motion rabbits |
| 基金项目:国家自然科学基金面上项目（81571635）、"数字诊疗装备研发"重点专项（2016YFC0106900）。 |
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| 中文摘要: |
| 目的 采用体素内不相干运动扩散成像（IVIM-DWI）和血氧水平依赖（BOLD）成像评估非离子型双聚体等渗碘对比剂对兔肾功能的影响。方法 将25只新西兰雄性兔均分为5组。对实验组（1、24、48、72 h组）分别在注射碘克沙醇后1、24、48、72 h行IVIM-DWI和BOLD扫描并采集血液，基线组注射等量生理盐水。扫描结束后处死兔，取肾脏进行组织病理学观察。结果 相比基线组，1 h组肾脏皮、髓质ADC值、D值、f值下降，D*值下降至最低，R2*值升高；24 h组肾皮质、髓质ADC值、D值、f值降至最低，D*值升高，R2*值最高；72 h组肾皮质、髓质R2*值仍低于基线值（P均<0.05），D*值基本恢复至基线水平，而髓质D值、f值仍未恢复至基线水平（P均<0.05）。病理显示各实验组存在不同程度肾小球及肾小管损伤。1 h组缺氧诱导因子1α和血红素加氧酶表达升高，24 h组最高；48、72 h组血肌酐及尿素氮均高于基线组（P均<0.05）。结论 IVIM-DWI联合BOLD可有效评估碘对比剂诱导的急性肾损伤兔肾脏病理生理变化。 |
| 英文摘要: |
| Objective To explore the impact of non-ionic dimeric isotonic iodine contrast agent on rabbit kidneys using intravoxel incoherent motion (IVIM)-DWI and blood oxygen level-dependent (BOLD) imaging. Methods Totally 25 male New Zealand rabbits were randomly equally divided into 5 groups (each n=5). IVIM-DWI and BOLD scanning and blood collection were performed in four experimental groups (1, 24, 48, 72 h group) 1, 24, 48,72 h after injection of iodixanol, respectively, also in base-line group after injection of equal amount of saline. The rabbits were killed immediately after MRI,and the kidneys were taken for histopathological analysis. Results Compared with base-line group, both cortex and medulla of kidneys showed decreased ADC, D and f values and the lowest D* value, as well as increased R2* in 1 h group. The lowest ADC, D and f values, the highest R2* and increased D* value of both cortex and medulla were observed in 24 h group. In 72 h group, R2* value of both cortex and medulla were still lower than baseline (all P<0.05), and D* value basically returned to baseline, while f and D values of medulla were still statistically different with respect to baseline (all P<0.05). Meanwhile, different degrees of glomerular and tubular damage were observed in the pathological sections. The serum creatinine and blood urea nitrogen in 48 h group and 72 h group were higher than those in base-line group (all P<0.05). The expression of hypoxia inducible factor-1α and heme oxygenase-1 increased in 1 h group and up to peak in 24 h group. Conclusion Combining IVIM-DWI with BOLD can effectively evaluate rabbit renal pathophysiologic changes associated with contrast-induced acute kidney injury. |
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