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徐臣,孙洪赞.¹⁸F-FDG PET/CT参数联合临床特征预测手术治疗早期宫颈癌患者预后[J].中国医学影像技术,2020,36(1):106~110

¹⁸F-FDG PET/CT参数联合临床特征预测手术治疗早期宫颈癌患者预后

¹⁸F-FDG PET/CT parameters combined with clinical features in predicting prognosis of patients with early cervical cancer

投稿时间：2019-03-11 修订日期：2019-08-28

DOI：10.13929/j.issn.1003-3289.2020.01.030

中文关键词: 子宫颈肿瘤 18F氟脱氧葡萄糖淋巴结预后

英文关键词:uterine cervical neoplasms Fluorodeoxyglucose F18 lymph nodes prognosis

基金项目:国家自然科学基金青年科学基金项目（81401438）、辽宁省重点研发计划指导计划项目（2017225012）。

作者	单位	E-mail
徐臣	中国医科大学附属盛京医院放射科, 辽宁沈阳 110004
孙洪赞	中国医科大学附属盛京医院放射科, 辽宁沈阳 110004	sunhongzan@126.com

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中文摘要:

目的探讨¹⁸F-FDG PET/CT参数联合临床特征对预测早期宫颈癌患者手术治疗后预后的价值。方法回顾性分析70例术前接受¹⁸F-FDG PET/CT检查的早期宫颈癌患者，比较术后复发组与无复发组间代谢参数的差异，评价¹⁸F-FDG PET/CT参数结合临床特征对预后的预测价值。结果术后平均随访（53.86±15.74）个月，期间11例（11/70，15.71%）肿瘤复发。相关¹⁸F-FDG PET/CT参数中，峰值标准摄取值（SUV_peak）可预测肿瘤复发（AUC=0.672，P=0.03）。多因素比例风险模型（Cox）显示，淋巴结转移状态及SUV_peak是最主要的预测因素。结论 SUV_peak和淋巴结转移状态是评价手术治疗后早期宫颈癌患者预后的主要指标。

英文摘要:

Objective To explore the prognostic value of ¹⁸F-FDG PET/CT parameters combined with clinical features in predicting prognosis of early cervical cancer patients after surgical operation. Methods A total of 70 cervical cancer patients who underwent ¹⁸F-FDG PET/CT before operation were collected and retrospectively analyzed. Differences of metabolic parameters were compared between relapsed patients (relapse group) and non-recurrent ones (non-recurrent group). The predictive value of ¹⁸F-FDG PET/CT parameters combined with clinical features for prognosis were analyzed. Results The mean follow-up time was (53.86±15.74) months, and recurrence of cervical cancer occurred in 11 patients (11/70, 15.71%). The peak standard uptake value (SUV_peak) was the only ¹⁸F-FDG PET/CT parameter predicting recurrence (AUC=0.672, P=0.03). Multivariate proportional hazards model (Cox) showed that lymph node metastatic status and SUV_peak were the most important predictors. Conclusion SUV_peak and lymph node metastatic status are main indicators for evaluating prognosis of patients with early cervical cancer after surgical operation.

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