| 崔碧霄,张苗,马杰,杨宏伟,马妍,焦力群,赵国光,卢洁.一体化18F-FDG PET/MR评估缺血性脑血管病[J].中国医学影像技术,2019,35(12):1817~1822 |
| 一体化18F-FDG PET/MR评估缺血性脑血管病 |
| Hybrid 18F-FDG PET/MR evaluation of ischemic cerebrovascular disease |
| 投稿时间：2019-05-13 修订日期：2019-07-21 |
| DOI：10.13929/j.1003-3289.201905104 |
| 中文关键词: 脑缺血 脑血管循环 放射性核素显像 氟脱氧葡萄糖18F 磁共振成像 |
| 英文关键词:brain ischemia cerebrovascular circulation radionuclide imaging fluorodeoxyglucose F 18 magnetic resonance imaging |
| 基金项目:国家自然科学基金面上项目（81671662）、北京市医院管理局"登峰"计划专项经费（DFL20180802）。 |
| 作者 | 单位 | E-mail | | 崔碧霄 | 首都医科大学宣武医院核医学科, 北京 100053 | | | 张苗 | 首都医科大学宣武医院放射科, 北京 100053 | | | 马杰 | 首都医科大学宣武医院核医学科, 北京 100053 | | | 杨宏伟 | 首都医科大学宣武医院核医学科, 北京 100053 | | | 马妍 | 首都医科大学宣武医院神经外科, 北京 100053 | | | 焦力群 | 首都医科大学宣武医院神经外科, 北京 100053 | | | 赵国光 | 首都医科大学宣武医院神经外科, 北京 100053 | | | 卢洁 | 首都医科大学宣武医院核医学科, 北京 100053
首都医科大学宣武医院放射科, 北京 100053
磁共振成像脑信息学北京市重点实验室, 北京 100053 | imaginglu@hotmail.com |
|
| 摘要点击次数: 2029 |
| 全文下载次数: 752 |
| 中文摘要: |
| 目的 探讨一体化18F-FDG PET/MR显像对于慢性缺血性脑血管病的应用价值。方法 对10名成年健康志愿者及17例慢性单侧颈内动脉（ICA）或大脑中动脉（MCA）闭塞患者行一体化18F-FDG PET/MR检查。由2名医师分析图像，定量分析和比较健康志愿者左侧与右侧不同脑区、慢性缺血性脑血管病患者脑梗死患侧与对侧相应区域及脑梗死周围区与对侧相应区域间平均ADC值（ADCmean）、平均标准化摄取值（SUVmean）及最大标准化摄取值（SUVmax）的差异。结果 10名健康志愿者MRI均未见异常，18F-FDG脑代谢图像清晰，各脑区代谢分布对称；左侧与右侧额叶、顶叶、颞叶、枕叶ADCmean、SUVmean、SUVmax差异均无统计学意义（P均>0.05）。17例慢性缺血性脑血管病MRI均可见脑梗死灶，18F-FDG脑代谢图显示患侧均较对侧相应区域ADCmean、SUVmean、SUVmax明显减低（P均<0.01）；脑梗死周围区与对侧相应区域比较ADCmean、SUVmean、SUVmax亦明显减低（P均<0.01）。结论 利用一体化18F-FDG PET/MR检查可同时获得脑结构和脑代谢综合信息，全面评价慢性缺血性脑血管病。 |
| 英文摘要: |
| Objective To investigate the value of hybrid 18F-FDG PET/MR in patients with ischemic cerebrovascular disease. Methods A total of 10 healthy volunteers and 17 patients with chronic unilateral internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion underwent hybrid 18F-FDG PET/MR examination. The images were analyzed by two experienced physicians. The mean ADC value (ADCmean), mean standardized uptake value (SUVmean) and the maximum standardized uptake value (SUVmax) were analyzed between left and right brain regions of healthy volunteers. ADCmean, SUVmean and SUVmax of corresponding areas of the cerebral infarction and contralateral corresponding areas, the surrounding areas of the cerebral infarction and contralateral side of patients were also compared. Results MRI of 10 healthy volunteers showed no abnormal performance. 18F-FDG images were clear and the metabolic distribution of each brain region was symmetrical. ADCmean, SUVmean, SUVmax were not statistically different between the left and right brain regions (all P>0.05). The cerebral infarctions were observed in MRI of 17 patients, and ADCmean, SUVmean and SUVmax significantly reduced on the affected side (all P<0.01), while ADCmean, SUVmean and SUVmax also significantly reduced in the surrounding areas of the cerebral infarction (all P<0.01). Conclusion Hybrid 18F-FDG PET/MR examination can evaluate patients with chronic ischemic cerebrovascular disease and provide information of brain structure and brain metabolism. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
