| 王静,李艳梅,赵倩,马扬,孙宵,李娟.18F-FDG PET/CT显像评估肺癌患者预后[J].中国医学影像技术,2019,35(7):1028~1032 |
| 18F-FDG PET/CT显像评估肺癌患者预后 |
| 18F-FDG PET/CT in prognostic evaluation of patients with lung cancer |
| 投稿时间：2018-10-20 修订日期：2019-05-10 |
| DOI：10.13929/j.1003-3289.201810143 |
| 中文关键词: 肺肿瘤 正电子发射型断层显影术 氟脱氧葡萄糖F18 预后 |
| 英文关键词:lung neoplasms positron-emission tomography fluorodeoxyglucose F 18 prognosis |
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| 摘要点击次数: 3009 |
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| 中文摘要: |
| 目的 分析18F-FDG PET/CT评估肺癌患者预后的价值。方法 回顾性分析109例肺癌患者的18F-FDG PET/CT及临床资料，测量病灶最大标准摄取值（SUVmax），并计算SUVmax与肿瘤最大径（D）比值（SUVmax/D）。采用Kaplan-Merier法绘制生存曲线，以COX单因素及多因素回归模型分析肺癌患者无进展生存期及总生存期的影响因素。结果 109例患者SUVmax为1.50~34.90，中位数为7.90；SUVmax/D为1.88~6.86 cm-1，中位数为1.90 cm-1；中位总生存期22个月，中位无进展生存期19个月。单因素COX回归分析结果显示，SUVmax、临床分期、SUVmax/D是无进展生存期的影响因素，SUVmax、临床分期、D是总生存期的影响因素（P均<0.05）。多因素COX回归分析显示，SUVmax、临床分期是无进展生存期及总生存期的独立预测因子（P均<0.01）。结论 肺癌病灶SUVmax、SUVmax/D对患者生存期有预测价值；SUVmax可能作为生存期的独立预测因子。 |
| 英文摘要: |
| Objective To investigate the prognostic value of 18F-FDG PET/CT in patients with lung cancer. Methods 18F-FDG PET/CT data and clinical data of 109 patients with lung cancer were retrospectively analyzed. The maximum standard value (SUVmax) of the lesion was measured, and the ratio of SUVmax to the largest tumor diameter (SUVmax/D) was calculated. Kaplan-Merier method was used to draw the survival curve, and COX univariate and multivariate regression models were used to analyze the impact factors of progression-free survival (PFS) and overall survival (OS) in patients with lung cancer. Results SUVmax of all 109 patients with lung cancer was 1.50-34.90, median SUVmax was 7.90, SUVmax/D was 1.88-6.86 cm-1, median SUVmax/D was 1.90 cm-1, median OS was 22 months, and median PFS was 19 months. Univariate COX regression analysis showed that SUVmax, clinical staging and SUVmax/D were the impact factors for PFS (all P<0.05), while SUVmax, clinical staging and the largest tumor diameter were the impact factors for OS (all P<0.01). Multivariate COX regression analysis showed that SUVmax and clinical stage were independent predictors of PFS and OS of patients with lung cancer (all P<0.01). Conclusion SUVmax and SUVmax/D of tumors have predictive value for prognosis of patients with lung cancer, and SUVmax may be an independent predictor of survival. |
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