| 张欢,阎锋,王红,黄建波,彭玉兰.VEGFR2靶向超声造影诊断乳腺癌研究进展[J].中国医学影像技术,2019,35(3):463~466 |
| VEGFR2靶向超声造影诊断乳腺癌研究进展 |
| Progresses of VEGFR2 targeted ultrasound contrastimaging in diagnosis of breast cancer |
| 投稿时间：2018-06-28 修订日期：2018-10-01 |
| DOI：10.13929/j.1003-3289.201806150 |
| 中文关键词: 乳腺肿瘤 超声检查 血管内皮生长因子受体 造影剂 |
| 英文关键词:breast neoplasms ultrasonography vascular endothelial growth factor receptor contrast media |
| 基金项目:国家自然科学基金面上项目（81571694）。 |
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| 中文摘要: |
| 肿瘤新生血管对乳腺癌的生长及转移具有重要作用。血管内皮细胞生长因子受体2（VEGFR2）在肿瘤新生血管内皮细胞中过量表达。超声分子显像（USMI）是通过靶向超声造影剂识别病变血管内皮细胞特异性表达靶点的新技术。大量实验及初步临床研究发现，以VEGFR2为靶向超声造影剂的USMI可用于诊断乳腺癌。本文对VEGFR2靶向超声造影诊断乳腺癌的研究进展进行综述。 |
| 英文摘要: |
| Tumor angiogenesis plays an important role in growth and metastasis of breast cancer. Vascular endothelial growth factor receptor 2 (VEGFR2) is over-expressed on tumor neo-angiogenesis endothelial cells. Ultrasound molecular imaging (USMI) is a new technology to identify the specific expression of vascular endothelial cells by targeted ultrasound contrast agent (tUCAs). A large number of experimental and preliminary clinical studies have demonstrated that USMI with VEGFR2 tUCAs could be used to diagnose breast cancer. The progresses of VEGFR2 targeted ultrasound contrast imaging in the diagnosis of breast cancer were reviewed in this article. |
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