| 郭定波,陈暇女,欧芳元,黄俊浩,易小琦,胡良波.动态增强MRI及1H-MRS诊断乳腺癌:Meta分析[J].中国医学影像技术,2019,35(3):371~375 |
| 动态增强MRI及1H-MRS诊断乳腺癌:Meta分析 |
| Dynamic contrast-enhanced MRI and 1H-MRS in diagnosis of breast cancer: Meta-analysis |
| 投稿时间：2018-06-13 修订日期：2018-09-28 |
| DOI：10.13929/j.1003-3289.201806064 |
| 中文关键词: 乳腺肿瘤 磁共振成像 综合分析 |
| 英文关键词:breast neoplasms magnetic resonance imaging meta-analysis |
| 基金项目:重庆市卫生计生委医学科研计划重点项目（2017ZDXM020）、重庆市永川区自然科学基金（Ycstc，2015nc5007）。 |
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| 中文摘要: |
| 目的 采用Meta分析方法评价动态增强MRI（DCE-MRI）、1H-MRS及两者联合对乳腺癌的诊断效能。方法 于PubMed、Embase、Cochrane Library、CNKI、万方、维普数据库检索DCE-MRI、1H-MRS及两者联合诊断乳腺癌的相关文献，检索时间自建库至2018年5月。采用Meta-Disc 1.4及STATA 12.0统计分析软件进行Meta分析。结果 共纳入14篇文献。DCE-MRI、1H-MRS及两者联合诊断乳腺癌的敏感度分别为0.93[95% CI（0.90，0.95）]、0.80[95% CI（0.76，0.83））和0.95[95% CI（0.92，0.97）]，特异度分别为0.77[95% CI（0.73，0.82）]、0.81[95% CI（0.77，0.85）]和0.83[95% CI（0.77，0.87）]，诊断比值比分别为43.69[95% CI（28.38，67.26）]、24.24[95% CI（16.24，36.16））和95.64[95% CI（48.90，187.07）），汇总受试者工作特征曲线AUC分别为0.932 9、0.899 9和0.961 9。结论 DCE-MRI及1H-MRS均为乳腺癌的有效诊断方法，两者联合应用诊断效果更佳。 |
| 英文摘要: |
| Objective To observe the diagnostic value of dynamic contrast-enhanced MRI (DCE-MRI), 1H-MRS and the combination of them for breast cancer using Meta-analysis. Methods Literatures from PubMed, Embase, Cochrane Library, CNKI, Wanfang and VIP databases were searched from establishment to May 2018, for the diagnostic studies about breast cancer by DCE-MRI, 1H-MRS and the combination of these two methods. Meta-Disc 1.4 and STATA 12.0 software were used for Meta-analysis. Results Totally 14 studies were enrolled. The pooled sensitivity of DCE-MRI, 1H-MRS and the combination of these two methods in diagnosing breast cancer was 0.93 (95%CI[0.90, 0.95]), 0.80 (95%CI[0.76, 0.83]) and 0.95 (95%CI[0.92,0.97]), the pooled specificity was 0.77 (95%CI[0.73, 0.82]), 0.81 (95%CI[0.77, 0.85]) and 0.83 (95%CI[0.77, 0.87]), the pooled diagnostic odds ratio was 43.69 (95%CI[28.38,67.26]), 24.24 (95%CI[16.24,36.16]) and 95.64 (95%CI[48.90, 187.07]), the AUC of summary receiver operating characteristic curve was 0.932 9, 0.899 9 and 0.961 9, respectively. Conclusion DCE-MRI and 1H-MRS are both effective diagnostic technique for breast cancer, and the combination of these two methods can provide more preferable diagnostic accuracy than single use of them. |
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