| 庞彩霞,胡波,魏亚萍,杨华峰.钙化及非钙化乳腺导管内原位癌超声特征及其雌激素受体和人表皮生长因子受体-2表达[J].中国医学影像技术,2019,35(3):367~370 |
| 钙化及非钙化乳腺导管内原位癌超声特征及其雌激素受体和人表皮生长因子受体-2表达 |
| Ultrasonographic features of calcified and non-calcified ductal carcinoma in situ of breast and their expression of estrogen receptor and human epidermal growth factor receptor-2 |
| 投稿时间：2018-08-05 修订日期：2018-12-09 |
| DOI：10.13929/j.1003-3289.201808030 |
| 中文关键词: 乳腺肿瘤 癌,导管内,非浸润性 钙化 受体,雌激素 人表皮生长因子受体-2 超声检查 |
| 英文关键词:breast neoplasms carcinoma,intraductal,noninfiltrating calcification receptors,estrogen human epidermal growth factor receptor-2 ultrasonography |
| 基金项目:宁波市自然科学基金（2011A610055）。 |
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| 中文摘要: |
| 目的 探讨钙化与非钙化乳腺导管内原位癌（DCIS）超声表现及其雌激素受体（ER）、人表皮生长因子受体-2（Her-2）表达的差异。方法 回顾性分析148例经手术病理证实的乳腺DCIS患者的超声征象，根据超声是否检出微钙化分为钙化组（n=66）和非钙化组（n=82），比较2组声像图特征和ER、Her-2表达阳性率的差异。结果 钙化组与非钙化组DCIS在是否探及肿块、导管扩张、弹性成像评分差异有统计学意义（P均<0.05），而边缘毛刺、后方回声、阻力指数及纵横比差异均无统计学意义（P均>0.05）。钙化组DCIS患者ER阳性表达率为42.42%（28/66），非钙化组为69.51%（57/82），差异有统计学意义（P<0.01）；钙化组DCIS患者Her-2阳性表达率为30.30%（20/66），非钙化组为14.63%（12/82），差异有统计学意义（P=0.02）。结论 钙化与非钙化DCIS超声表现存在差异，非钙化DCIS患者ER阳性表达率高，钙化DCIS患者Her-2阳性表达率高，提示伴钙化的DCIS更具侵袭性。 |
| 英文摘要: |
| Objective To compare the ultrasonographic features of calcified and non-calcified ductal carcinoma in situ (DCIS) of breast, and to explore the difference of the expression of estrogen receptor (ER) and human epidermal growth factor receptor-2 (Her-2). Methods A total of 148 patients with pathologically confirmed DCIS were retrospectively analyzed and divided into calcified DCIS group (n=66) and non-calcified DCIS group (n=82) according to the presence of microcalcification in ultrasonography. The differences of the ultrasonographic features, ER and Her-2 positive expression were analyzed. Results The signs of mass, ductal ectasia and elastographic scores showed statistically significant differences between the 2 groups (all P<0.05), while the signs of spiculation, posterior echo attenuation, resistance index and aspect ratio showed no statistically significant difference (all P>0.05). ER positive rate was 42.42% (28/66) in calcified DCIS group and 69.51% (57/82) in non-calcified DCIS group. The difference of ER positive rate between the two groups was statistically significant (P<0.01). Her-2 positive in calcified DCIS group was 30.30% (20/66), while in the non-calcified DCIS group was 14.63% (12/82; P=0.02). Conclusion The ultrasonographic features are different between calcified breast DCIS and non-calcified DCIS. Positive ER is more common in non-calcified DCIS, while high Her-2 expression is more common in calcified DCIS, indicating that calcified DCIS may have rather aggressive histological features. |
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