| 尹海军,冯天鹰,红华,郭耀霞,郎瑞.速度向量成像技术定量评价联合化疗乳腺癌患者左心室心肌损害[J].中国医学影像技术,2019,35(3):341~346 |
| 速度向量成像技术定量评价联合化疗乳腺癌患者左心室心肌损害 |
| Quantitative evaluation of left ventricular myocardium damage in patients with breast cancer after combined chemotherapy using velocity vector imaging |
| 投稿时间：2018-08-20 修订日期：2018-12-21 |
| DOI：10.13929/j.1003-3289.201808125 |
| 中文关键词: 乳腺肿瘤 速度向量成像 心肌损害 药物疗法,联合 超声心动描记术 |
| 英文关键词:breast neoplasms velocity vector imaging myocardial damage drug therapy,combination echocardiography |
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| 中文摘要: |
| 目的 采用速度向量成像（VVI）技术定量评估联合化疗方案对乳腺癌患者心肌损害程度。方法 将65例人表皮生长因子受体2（HER-2）阳性乳腺癌患者根据化疗方案不同分为CETH组（联合化疗方案+赫赛汀）和CET组（联合化疗方案），分别于化疗前1天、化疗第5周期末、第7周期末行常规超声心动图及VVI检查，分析常规超声参数和左心室各节段收缩期峰值应变率（SSR）及舒张早期峰值应变率（DSR）。结果 CETH组与CET组间化疗前、化疗第5、7周期末常规超声参数差异均无统计学意义（P均>0.05）。2组患者化疗前、化疗第5、7周期末左心室16节段SSR、DSR总体差异均有统计学意义（P均<0.05），且随化疗时间延长，SSR、DSR逐渐减低，两两比较差异均有统计学意义（P均<0.05）。化疗第7周期末，CETH组患者左心室各节段SSR、DSR均较CET组患者减低（P均<0.05）。结论 VVI技术较常规超声显示左心室心肌损害更敏感，可定量评估不同化疗方案对乳腺癌患者的心肌损害。 |
| 英文摘要: |
| Objective To investigate the value of velocity vector imaging (VVI) in quantitatively evaluating the degree of myocardial damage in breast cancer patients treated with combined chemotherapy. Methods Totally 65 patients with human epidermal growth factor receptor-2 (HER-2) positive breast cancer were divided into CETH group (combined chemotherapy with Herceptin) and CET group (combined chemotherapy). Routine echocardiography and VVI were performed before chemotherapy and at the end of the 5th and 7th chemotherapy cycles, respectively. The parameters of conventional echocardiography, systolic strain rate (SSR) and early diastolic strain rate (DSR) were analyzed. Results No significant difference of ultrasound parameters was found between CETH group and CET group before and at the end of the 5th, 7th cycles of chemotherapy (all P>0.05). In both CETH group and CET group, there were significant differences of SSR and DSR in 16 segments of left ventricle before and at the end of the 5th and 7th cycles of chemotherapy (all P<0.05). With the prolongation of chemotherapy time, SSR and DSR decreased gradually, and there were significant differences between each of the two time points (all P<0.05). At the end of the 7th cycle of chemotherapy, SSR and DSR of left ventricular segments in CETH group were lower than those in CET group (all P<0.05). Conclusion VVI is more sensitive than conventional echocardiography in detecting left ventricular myocardial damage, which can quantitatively assess myocardial damage of breast cancer patients with different chemotherapy regimens. |
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