| 李昊元,王铁,杨敏福.特发性间质性肺炎患者18F-FDG PET/CT与肺功能及炎性指标的相关性[J].中国医学影像技术,2019,35(2):209~213 |
| 特发性间质性肺炎患者18F-FDG PET/CT与肺功能及炎性指标的相关性 |
| Correlation of 18F-FDG PET/CT and pulmonary function and inflammatory biomakers in patients with idiopathic interstitial pneumonia |
| 投稿时间：2018-07-16 修订日期：2018-11-13 |
| DOI：10.13929/j.1003-3289.201807118 |
| 中文关键词: 特发性间质性肺炎 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术,X线计算机 |
| 英文关键词:idiopathic interstitial pneumonias fludeoxyglucose F 18 positron-emission tomography tomography, X-ray computed |
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| 中文摘要: |
| 目的 观察特发性间质性肺炎（ⅡP）患者18F-FDG PET/CT显像与肺功能及实验室炎性指标的关系。方法 回顾性分析20例ⅡP患者（ⅡP组）和20例肺部正常患者（对照组）的PET/CT图像，测量全肺最大标准摄取值（SUVmax）和平均标准摄取值（SUVmean），并校正获得最大靶背景比（TBRmax）和平均靶背景比（TBRmean），比较ⅡP组与对照组间SUV和TBR的差异，评价ⅡP组TBR与肺功能及炎性指标的相关性。结果 ⅡP组SUVmax、SUVmean、TBRmax和TBRmean均显著高于对照组（P均<0.001）。ⅡP组TBRmean与用力肺活量（FVC，r=-0.811，P=0.004）、肺一氧化碳弥散量（DLCO，r=-0.715，P=0.020）、第1秒用力呼气量（FEV1，r=-0.698，P=0.025）、残气量（RV，r=-0.844，P=0.002）、肺总量（TLC，r=-0.693，P=0.026）及RV/TLC（r=-0.711，P=0.021）呈负相关，与FEV1/FVC（r=0.888，P=0.001）呈正相关。TBRmax与FVC（r=-0.667，P=0.035）和RV（r=-0.643，P=0.045）呈负相关，与DLCO、FEV1、FEV1/FVC、TLC、RV/TLC无明显相关性（P均>0.05）。ⅡP组TBRmax和TBRmean分别与红细胞沉降率、C反应蛋白均无明显相关性（P均>0.05）。结论 ⅡP患者18F-FDG放射性摄取增高，其程度与肺功能具有一定相关性。 |
| 英文摘要: |
| Objective To explore the relationship of 18F-FDG PET/CT imaging and pulmonary function and laboratory inflammatory biomarkers in patients with idiopathic interstitial pneumonia (ⅡP). Methods PET/CT imaging of 20 patients with ⅡP (ⅡP group) and 20 patients without pulmonary lesions (control group) were retrospectively analyzed. The maximum standard uptake value (SUVmax) and mean SUV (SUVmean) of the whole lung were measured, and the maximum target-to-back ratio (TBRmax) and mean TBR (TBRmean) were calculated. SUV and TBR were compared between ⅡP group and control group, and the correlation of TBR and pulmonary function indexes and inflammatory biomarkers in ⅡP group were evaluated. Results SUVmax, SUVmean, TBRmax and TBRmean in ⅡP group were significantly higher than those in control group (all P<0.001). In ⅡP group, negative correlation of TBRmean and forced vital capacity (FVC, r=-0.811, P=0.004), diffusion capacity for carbon monoxide of the lung (DLCO, r=-0.715, P=0.020), forced expiratory volume in 1 second (FEV1, r=-0.698, P=0.025), residual volume (RV, r=-0.844, P=0.002), total lung capacity (TLC, r=-0.693, P=0.026) and RV/TLC (r=-0.711, P=0.021) were observed, as well as positive correlation between TBRmean and FEV1/FVC (r=0.888, P=0.001). There were negative correlations of TBRmax and FVC (r=-0.667, P=0.035) and RV (r=-0.643, P=0.045), while no obvious correlation was found between TBRmax and DLCO, FEV1, FEV1/FVC, TLC, RV/TLC (all P>0.05), nor between TBR and erythrocyte sedimentation rate and C-reaction protein (both P>0.05). Conclusion The radioactive uptake increases in ⅡP patients, which has certain correlation with pulmonary function. |
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