| 尚琨,乔洪文,卢洁,崔碧霄,苏玉盛,李则,梁志刚.18F-FDG及18F-FP-DTBZ双示踪PET/CT显像诊断帕金森病[J].中国医学影像技术,2018,34(11):1615~1620 |
| 18F-FDG及18F-FP-DTBZ双示踪PET/CT显像诊断帕金森病 |
| 18F-FDG and 18F-FP-DTBZ PET/CT imaging in diagnosis of Parkinson disease |
| 投稿时间：2018-03-25 修订日期：2018-08-22 |
| DOI：10.13929/j.1003-3289.201803156 |
| 中文关键词: 帕金森病 氟脱氧葡萄糖F18 Ⅱ型囊泡单胺转运体 体层摄影术,发射型计算机 |
| 英文关键词:Parkinson disease Fludeoxyglucose F 18 Vesicular monoamine transporter type 2 Tomography, emission-computed |
| 基金项目:十三五国家重点研发项目（2016YFC0103000）。 |
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| 中文摘要: |
| 目的 探讨18F-FDG及18F-FP-DTBZ双示踪PET/CT显像诊断帕金森病（PD）的价值。方法 对28例PD患者（PD组）和10名健康志愿者（对照组）行18F-FDG脑代谢和18F-FP-DTBZ PET/CT显像。对PD患者采用PD统一评分量表第Ⅲ部分（UPDRS Ⅲ）和Hoehn-Yahr（H-Y）进行临床评分。在18F-FDG PET图像上观察代谢减低脑区；在18F-FP-DTBZ PET图像上测得尾状核、壳核前部及壳核后部标准摄取值（SUV）。比较PD组与对照组间的差异，并与临床评分进行相关性分析。结果 PD组中23例（23/28，82.14%）大脑皮层代谢减低，8例（8/28，28.57%）基底核代谢减低。PD组尾状核18F-FP-DTBZ SUV与对照组差异无统计学意义（P=0.118），壳核前部及后部SUV均低于对照组（P均<0.01）。PD组早期PD患者尾状核18F-FP-DTBZ SUV与对照组差异无统计学意义（P>0.05），壳核前部及后部18F-FP-DTBZ SUV均低于对照组（P均<0.01）；中晚期PD患者尾状核、壳核前部及后部18F-FP-DTBZ SUV均低于对照组（P均<0.05）。壳核前部及后部18F-FP-DTBZ SUV均与UPDRS Ⅲ运动评分、H-Y分期均呈负相关（壳核前部：r=-0.463、-0.564，P=0.002、0.001；壳核后部：r=-0.412、-0.585，P=0.005、0.001）。单侧肢体症状PD患者症状对侧壳核前部及后部18F-FP-DTBZ SUV较症状侧减低（P均<0.05）。结论 18F-FDG及18F-FP-DTBZ双示踪PET/CT显像可为诊断PD和评估病情提供有益信息。 |
| 英文摘要: |
| Objective To explore the value of 18F-FDG and 18F-FP-DTBZ PET/CT imaging in diagnosis of Parkinson disease (PD). Methods Totally 28 PD patients (PD group) and 10 healthy controls (control group) were recruited. Brain 18F-FDG and 18F-FP-DTBZ PET/CT were performed. The unified Parkinson disease rating scale motor score part Ⅲ (UPDRS Ⅲ) and Hoehn-Yahr (H-Y) scale were used to evaluate the clinical state. The regions with hypometabolism were found on 18F-FDG PET images, and the standard uptake value (SUV) of caudate nuclei, anterior and posterior putamen were acquired on 18F-FP-DTBZ PET images and compared between the two groups, the correlation of SUV with UPDRS Ⅲ and H-Y scores was evaluated. Results In PD group, the hypometabolism of 18F-FDG at cortex was found in 23 patients (23/28, 82.14%) and at basal ganglia in 8 (8/28, 28.57%). There was no significant difference of 18F-FP-DTBZ SUV at caudate nuclei between the two groups (P=0.118). SUV at anterior and posterior putamen decreased significantly compared with control group (both P<0.01). Compared with control group, 18F-FP-DTBZ SUV at caudate nuclei had no significant difference (P>0.05), while SUV at anterior and posterior putamen decreased in early-stage PD patients of PD group (both P<0.01). Among advanced stage PD patients of PD group, SUV at caudate nuclei, anterior and posterior putamen were all lower than those in control group (all P<0.05). 18F-FP-DTBZ SUV in anterior and posterior putamen showed obvious negative correlation with UPDRS Ⅲ and H-Y scores (anterior putamen:r=-0.463, -0.564, P=0.002, 0.001; posterior putamen:r=-0.412, -0.585, P=0.005, 0.001). In PD patients with unilateral symptoms, 18F-FP-DTBZ SUV decreased at the contralateral anterior and posterior putamen than at ipsilateral putamen (both P<0.05). Conclusion 18F-FDG and 18F-FP-DTBZ PET/CT imaging can provide useful information in diagnosis and evaluation of PD patients. |
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