| 何娇,刘健,文宏,周琳.经皮CEUS定位和定性诊断早期乳腺癌前哨淋巴结[J].中国医学影像技术,2018,34(9):1364~1367 |
| 经皮CEUS定位和定性诊断早期乳腺癌前哨淋巴结 |
| Percutaneous CEUS in localization and qualitative diagnosis of sentinel lymph nodes in early breast cancer |
| 投稿时间：2018-01-28 修订日期：2018-06-11 |
| DOI：10.13929/j.1003-3289.201801172 |
| 中文关键词: 经皮 超声检查 造影剂 乳腺肿瘤 前哨淋巴结 |
| 英文关键词:Percutaneous Ultrasonography Contrast media Breast neoplasms Sentinel lymph node |
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| 中文摘要: |
| 目的 探讨经皮CEUS对早期乳腺癌前哨淋巴结（SLN）定位和定性诊断价值。方法 收集75例经病理证实的早期乳腺癌患者，在乳晕周围皮下注射超声造影剂（声诺维）行CEUS，实时、连续观察显影淋巴管及SLN增强模式，并于体表标记淋巴管及SLN。注射亚甲蓝后行前哨淋巴结活检术（SLNB），计算经皮CEUS定位SLN的准确率；以病理结果为金标准，计算CEUS诊断SLN性质的敏感度和特异度。结果 75例患者，术前经皮CEUS共检出116枚SLN，亚甲蓝示踪后SLNB获得163枚SLN，差异有统计学意义（Z=-2.651，P=0.008）。经皮CEUS定位腋窝SLNS的准确率为94.67%（71/75），且其诊断SLN性质的敏感度为98.04%（50/51），特异度为49.23%（32/65）。结论 经皮CEUS可作为SLNB术前定位的有效方法，其对早期乳腺癌SLN定性诊断的敏感度较高，而特异度较低。 |
| 英文摘要: |
| Objective To investigate the value of percutaneous CEUS in localization and qualitative diagnosis of sentinel lymph node (SLN) in patients with early breast cancer. Methods Totally 75 patients with pathologically proven early breast cancer were enrolled. The ultrasound contrast agent (SonoVue) was injected subcutaneously around the areola for CEUS. The lymphatic vessels and SLN enhancement patterns were observed in real time and continuously, and lymphatic vessels and SLNs were marked on the body surface. Sentinel lymph node biopsy (SLNB) was performed after injection of methylene blue to calculate the accuracy of percutaneous CEUS positioning of SLN. The sensitivity and specificity of CEUS in qualitative diagnosis of SLN were calculated taken pathological results as gold standards. Results Among75 patients, 116 SLNs were detected with percutaneous CEUS before operation, and 163 SLNs were obtained after methylene blue tracing in SLNB (Z=-2.651, P=0.008). The accuracy of localization of SLNs in axilla was 94.67% (71/75) with percutaneous CEUS, the sensitivity of qualitative diagnosis of SLNs was 98.04% (50/51) and the specificity was 49.23%(32/65). Conclusion Percutaneous CEUS can be used as an effective method to locate SLNs, which has high sensitivity and low specificity for qualitative diagnosis of SLNs in patients with early breast cancer. |
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