| 郑立春,刘桂超,张文军,张晓明,丁重阳.18F-FDG PET/CT显像评估胰头癌患者预后[J].中国医学影像技术,2018,34(8):1237~1241 |
| 18F-FDG PET/CT显像评估胰头癌患者预后 |
| Prognostic evaluation of 18F-FDG PET/CT in patients with pancreatic head carcinoma |
| 投稿时间：2018-01-22 修订日期：2018-05-23 |
| DOI：10.13929/j.1003-3289.201801133 |
| 中文关键词: 胰腺肿瘤 预后 体层摄影术,发射型计算机 体层摄影术,X线计算机 氟脱氧葡萄糖F18 |
| 英文关键词:Pancreatic neoplasms Prognosis Tomography, emission-computed Tomography X-ray computed Fluoro deoxyglucose F 18 |
| 基金项目:河北省医学科学研究重点课题（20150955）。 |
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| 中文摘要: |
| 目的 分析18F-FDG PET/CT在胰头癌患者预后评估中的价值。方法 回顾性分析65例胰头癌患者的临床及18F-FDG PET/CT显像资料，测量胰腺原发灶最大标准摄取值（SUVmax）、代谢肿瘤体积（MTV）和病灶糖酵解总量（TLG）。采用Cox比例风险模型获得胰腺癌患者预后的独立影响因素。结果 65例胰头癌患者，原发灶SUVmax、MTV、TLG分别为7.9（5.6，10.4）、13.1（7.3，22.5）cm3和68.6（32.2，95.7）。单因素生存分析结果显示，SUVmax、MTV、TLG、肿瘤最大径、淋巴结转移、肝转移、第8版美国癌症研究联合会分期、手术和化疗是胰头癌患者总生存期的影响因素（P均<0.05）；多因素分析结果显示，手术、化疗、MTV、TLG是胰头癌患者总生存期的独立影响因素（P均<0.05）。结论 18F-FDG PET/CT指标MTV、TLG是影响胰头癌患者预后的独立预后因素，对评估胰头癌患者预后具有一定价值。 |
| 英文摘要: |
| Objective To investigate the prognostic value of 18F-FDG PET/CT in patients with pancreatic head carcinoma. Methods The clinical and 18F-FDG PET/CT data of 65 patients with pancreatic head carcinoma were retrospectively analyzed. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) of primary lesions were measured or calculated. The Cox proportional hazards model was used to obtain the independent prognostic influencing factors of pancreatic head carcinoma. Results SUVmax, MTV and TLG of 65 patients with pancreatic head carcinoma was 7.9 (5.6, 10.4), 13.1 (7.3, 22.5)cm3 and 68.6 (32.2, 95.7), respectively. Univariate analysis showed that SUVmax, MTV, TLG, the maximal tumor length, lymphadenectasis, hepatic metastases, American Jiont Committe on Cancer stage, operation and chemotherapy were all significantly associated with overall survival time (all P<0.05). In multivariate analysis, the operation, chemotherapy, MTV and TLG were the independent influencing factors for overall survival time of patients with pancreatic head carcinoma (all P<0.05). Conclusion MTV and TLG of 18F-FDG PET/CT are the independent prognostic factors for predicting prognosis of patients with pancreatic head carcinoma, which can provide certain value for prognosis of patients with pancreatic head carcinoma. |
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