| 胡钰茗,刘娟,全凤英.经颅超声对我国帕金森病患者的诊断价值:Meta分析[J].中国医学影像技术,2018,34(8):1173~1177 |
| 经颅超声对我国帕金森病患者的诊断价值:Meta分析 |
| Diagnostic value of transcranial sonography for patients with Parkinson disease in China: Meta-analysis |
| 投稿时间：2017-12-31 修订日期：2018-04-24 |
| DOI：10.13929/j.1003-3289.201712162 |
| 中文关键词: 超声检查,多普勒,经颅 帕金森病 诊断 Meta分析 |
| 英文关键词:Ultrasonography, Doppler, transcranial Parkinson disease Diagnosis Meta-analysis |
| 基金项目: |
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| 中文摘要: |
| 目的 采用Meta分析的方法，评价我国经颅超声（TCS）对帕金森病（PD）患者的诊断价值。方法 检索建库至2017年11月间PubMed、Cochrone图书馆、CNKI和中国生物医学文献数据库中有关TCS诊断国人PD的文献，以诊断性试验准确性评价工具（QUADAS）评价纳入文献的质量，并采用Meta-disc 1.4软件进行数据分析，计算我国TCS诊断PD患者的汇总敏感度、特异度、阳性似然比、阴性似然比和诊断比值比，并绘制汇总受试者工作特征（SROC）曲线。结果 共纳入15篇文献，中文12篇，英文3篇，我国TCS诊断PD的敏感度范围为0.62~0.93，特异度范围为0.50~0.94。纳入研究存在异质性，采用随机效应模型进行分析。我国TCS诊断的汇总敏感度、特异度、阳性似然比、阴性似然比和诊断比值比及其95% CI分别为0.78（0.76，0.81）、0.85（0.83，0.88）、5.46（4.01，7.44）、0.22（0.17，0.29）和27.15（16.96，43.46），SROC曲线下面积为0.904 9，Q指数为0.836 5。结论 在我国，TCS诊断PD具有一定价值，可作为辅助检查手段。 |
| 英文摘要: |
| Objective To explore the diagnostic value of transcranial sonography (TCS) for Parkinson disease (PD) in China using Meta-analysis. Methods The papers about TCS in diagnosis of Chinese PD were searched in PubMed, Cochrane library, CNKI and China Biology Medicine Disc from establishment to November 2017. The quality of each included papers was evaluated with quality assessment of diagnostic accuracy studies (QUADAS) tools. Meta-Disc 1.4 software was used to conduct pooling on sensitivity, specificity, positive likelihood radio, negative likelihood ratio and diagnostic odds ratio of TCS in the diagnosis of PD in China. In addition, the summary receiver operating characteristic curve (SROC) was drawn. Results Totally 15 papers were enrolled, including 12 in Chinese and 3 in English. The reported sensitivity of TCS in diagnosis of PD in China ranged from 0.62 to 0.93, and the reported specificity ranged from 0.50 to 0.94. Significant heterogeneity was found among studies, and the random effect model was used. The pooled sensitivity, specificity, positive likelihood radio, negative likelihood ratio and diagnostic odds ratio of TCS in diagnosis of PD in China was 0.78 (0.76, 0.81), 0.85 (0.83, 0.88), 5.46 (4.01, 7.44), 0.22 (0.17, 0.29) and 27.15 (16.96, 43.46), respectively. The AUC and Q index was 0.904 9 and 0.836 5, respectively. Conclusion In China, TCS is a valuable method for diagnosis of PD, which can be used as an effective screening test in clinical practice. |
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