| 张苗,段绍峰,卢洁,李坤成,单保慈.基于图谱的纤维束分析方法观察皮质脊髓束扩散特征对称性[J].中国医学影像技术,2018,34(8):1165~1168 |
| 基于图谱的纤维束分析方法观察皮质脊髓束扩散特征对称性 |
| Observation on diffusion characteristic symmetry of corticospinal tract based on atlas fiber analysis |
| 投稿时间：2017-12-09 修订日期：2018-04-20 |
| DOI：10.13929/j.1003-3289.201712052 |
| 中文关键词: 磁共振成像 扩散张量成像 张量图谱 皮质脊髓束 对称 |
| 英文关键词:Magnetic resonance imaging Diffusion tensor imaging Tensor atlas Corticospinal tract Symmetry |
| 基金项目:国家自然科学基金优秀青年科学基金（81522021）、国家自然科学基金青年基金（81501436）。 |
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| 中文摘要: |
| 目的 应用基于张量图谱的纤维束分析方法定量分析健康成年人双侧皮质脊髓束扩散特征的对称性。方法 对15名健康成年志愿者的原始DTI数据构建扩散权重图像模板，采用explore DTI软件追踪全脑纤维束，提取双侧皮质脊髓束并对其进行重新定位和配准，分别获得各向异性分数（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）的特性曲线，并进行定量统计分析。结果 各参数曲线同一侧别不同格点的数值间比较差异均有统计学意义（P均<0.05）；FA曲线的左右侧平均值比较差异有统计学意义（P=0.005），而MD、AD及RD曲线左右两侧平均值的差异均无统计学意义（P均>0.05）；各参数曲线左右两侧对称部位格点的数值比较差异均无统计学意义（P均>0.999）。结论 健康成年人双侧皮质脊髓束的扩散特征具有对称性，可为研究病理状态下纤维束扩散特征的改变提供理论依据和参考模板。 |
| 英文摘要: |
| Objective To explore the symmetry of diffusion characteristics of bilateral corticospinal tract in healthy adults with atlas-based fiber analysis method. Methods Raw DTI data of 15 healthy adult volunteers were constructed as a diffusion weight image template. The whole-brain fiber bundle was tracked with exploring DTI software, and the corticospinal tract was extracted and registrated. The diffusion properties curves of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were obtained for quantitative statistical analysis. Results Values of different grid points at the same side of each parameter curve were statistically different (all P<0.05). Significant difference of FA curve was found between the two sides (P=0.005), while no significant difference of MD, AD nor RD curve was found between the two sides (all P>0.05). There were no statistically significant differences in the values of the symmetrical site between left and right side of each parameter curve (all P>0.999). Conclusion Symmetry of diffusion characteristics of bilateral corticospinal tract in healthy adults can provide theoretical basis and referent template for changes of fiber bundle in pathological conditions. |
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