| 谢青,敬丽,伍建林.终末期肾病患者认知功能损伤的静息态功能MRI研究进展[J].中国医学影像技术,2018,34(3):448~451 |
| 终末期肾病患者认知功能损伤的静息态功能MRI研究进展 |
| Research progresses of resting-state functional MRI in patients of end-stage renal disease patients with cognitive impairment |
| 投稿时间：2017-09-26 修订日期：2017-12-05 |
| DOI：10.13929/j.1003-3289.201709150 |
| 中文关键词: 肾衰竭,慢性 认知损伤 磁共振成像 静息态 |
| 英文关键词:Kidney failure,chronic Cognitive dysfunction Magnetic resonance imaging Resting-state |
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| 中文摘要: |
| 终末期肾病（ESRD）常伴随全身多器官功能损伤。认知功能损伤在ESRD患者中发病率较高，静息状态下脑活动异常是ESRD认知损伤的表现之一。静息态fMRI（rs-fMRI）可分为功能分离分析法和功能整合分析法两类，从不同方面反映大脑神经活动变化。rs-fMRI无创、无辐射且时间和空间分辨力较高，已逐渐成为认知损害神经生理机制的有效研究手段。本文对ESRD伴认知功能损伤的病理机制及rs-fMRI研究现状及进展进行综述。 |
| 英文摘要: |
| End-stage renal disease (ESRD) is often complicated with damage of multi-organ function, among them, cognitive impairment has been noticed with a high prevalence. The abnormal intrinsic brain activity patterns in resting state is one of the manifestations of cognitive impairment in ESRD. Resting-state functional MRI (rs-fMRI) is divided into two categories, i.e. functional separation and functional integration, reflecting the changes of neural activity of the brain in different aspects. With advantages of non-invasive, no radiation and high spatio-temporal resolution, rs-fMRI has gradually become an effective method in studying the neurophysiological mechanisms of cognitive impairment. The pathophysiology and research progresses of rs-fMRI in ESRD with cognitive impairment were reviewed in this article. |
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