| 高仁坎,徐慧,梁煜爽.维吾尔族女性三阴性乳腺癌MRI表现及其与Ki-67指数的相关性[J].中国医学影像技术,2018,34(3):362~366 |
| 维吾尔族女性三阴性乳腺癌MRI表现及其与Ki-67指数的相关性 |
| MRI features of triple-negative breast cancer and correlation with Ki-67 index in Uygur women |
| 投稿时间：2017-08-25 修订日期：2018-01-17 |
| DOI：10.13929/j.1003-3289.201708171 |
| 中文关键词: 乳腺肿瘤 磁共振成像 Ki-67抗原 |
| 英文关键词:Breast neoplasms Magnetic resonance imaging Ki-67 antigen |
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| 中文摘要: |
| 目的 探讨维吾尔族女性三阴性乳腺癌（TNBC）的MRI表现及其与Ki-67指数的相关性。方法 收集97例经病理证实的TNBC患者，其中维吾尔族28例（维吾尔族组；28个病灶），汉族69例（汉族组；70个病灶），比较两组MRI特征；分析维吾尔族组TNBC的MRI特征与Ki-67指数的相关性。结果 维吾尔族及汉族患者TNBC均以浸润性导管癌（3级）为主，两组间Ki-67指数及ADC值差异均无统计学意义（P均> 0.05）。维吾尔族患者年龄小于汉族患者（P<0.05），肿瘤最大径和早期强化率均大于汉族患者（P均< 0.05）；两组间TNBC病灶边缘、强化特征差异均有统计学意义（P均< 0.05）；维吾尔族组时间-信号强度曲线（TIC）类型以流出型为主，汉族组以平台型为主（P < 0.001）。维吾尔族组Ki-67指数与肿块形态及TIC类型呈正相关（r=0.464、0.606，P均< 0.05）。结论 维吾尔族女性TNBC的MRI特征与汉族女性有一定差异，且部分特征与Ki-67指数相关。 |
| 英文摘要: |
| Objective To investigate MRI findings of triple-negative breast cancer (TNBC) and correlation with Ki-67 index in Uygur women. Methods Totally 97 patients with pathologically confirmed TNBC were enrolled. Among them, 28 patients were Uygur nationality (Uygur group; 28 lesions) and 69 were Han nationality (Han group; 70 lesions). MRI features of the two groups were observed and compared, and the correlation between MRI findings and Ki-67 index in Uygur group was analyzed. Results The pathological type of TNBC in Uygur group and Han group was both mainly invasive ductal carcinoma (grade 3). There was no statistical difference of Ki-67 index nor ADC value between the two groups (both P>0.05). The Uygur patients were younger than Han patients (P<0.05) and maximum diameter of lesions and early enhancement rate in Uygur group were higher than those in Han group (all P<0.05). The margin and enhancement features of lesions were statistically different between the two groups (both P<0.05). The dominated type of time-signal intensity curve (TIC) in Uygur group was wash-out type, while in Han group was plateau type (P<0.001). The Ki-67 index was positively correlated with tumor shape and TIC type in Uygur group (r=0.464, 0.606, both P<0.05). Conclusion MRI features of Uygur women with TNBC is somewhat different from Han women, and part features are correlated with Ki-67 index. |
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