陈玲珑,曾献军.急性淋巴细胞白血病化疗相关认知损害的影像学研究进展[J].中国医学影像技术,2018,34(1):136~139 |
急性淋巴细胞白血病化疗相关认知损害的影像学研究进展 |
Advances in imaging technology of acute lymphoblastic leukemia related neurocognitive impairment |
投稿时间:2017-04-13 修订日期:2017-10-28 |
DOI:10.13929/j.1003-3289.201704064 |
中文关键词: 儿童 前体细胞淋巴母细胞白血病-淋巴瘤 化学治疗 神经认知功能障碍 磁共振成像 |
英文关键词:Child Precursor cell lymphoblastic leukemia-lymphoma Chemotherapy Neurocognitive dysfunction Magnetic resonance imaging |
基金项目:国家自然科学基金(8166070125)。 |
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中文摘要: |
急性淋巴细胞白血病是最常见的儿童期恶性肿瘤,随着个体化化疗的应用,治愈率日渐提高。但由于儿童时期大脑处于快速发育阶段,化疗药物可不同程度地直接或间接影响患儿神经认知功能,且作用方式复杂。本文对儿童期急性淋巴细胞化疗相关认知损害的病理生理学机制、神经功能、MRI等研究进展进行综述。 |
英文摘要: |
Acute lymphoblastic leukemia is the most common malignant tumor of children. Due to the application of individual chemotherapy, the cure rate of this disease is increasing. Because of the rapid development of brain in childhood, the chemotherapeutic drugs can affect the neurocognitive function of children in varying degrees. The progresses of pathophysiology, neurological function, MRI of acute lymphoblastic leukemia related neurocognitive impairment were reviewed in this article. |
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