| 张新超,边艳珠,国方娜,吴大勇,胡玉敬.比较PET/CT显像中肝脏18F-FDG摄取半定量分析方法[J].中国医学影像技术,2018,34(1):68~72 |
| 比较PET/CT显像中肝脏18F-FDG摄取半定量分析方法 |
| Comparison on semi-quantitative analysis methods of liver 18F-FDG uptake in PET/CT imaging |
| 投稿时间：2017-03-23 修订日期：2017-10-19 |
| DOI：10.13929/j.1003-3289.201703128 |
| 中文关键词: 体层摄影术,发射型计算机 标准化摄取值 瘦体质量 体表面积 肝脏 |
| 英文关键词:Tomography,emission-computed Standard uptake value Lean body mass Body surface area Liver |
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| 中文摘要: |
| 目的 探讨PET/CT显像中影响肝脏18F-FDG摄取的因素，分析常规体质量（BM）、瘦体质量（LBM）及体表面积（BSA）校正最大标准化摄取值（SUVmax-B、SUVmax-L、SUVmax-S）的应用价值。方法 回顾性分析行18F-FDG PET/CT显像的67名健康受检者。测量肝脏SUVmax-B、SUVmax-L及SUVmax-S，分析年龄、空腹血糖水平、体质量指数（BMI）、肝脏CT值、性别、脂肪肝对上述参数的影响。结果 空腹血糖水平与肝脏SUVmax-B、SUVmax-L、SUVmax-S均呈正相关（r=0.329、0.336、0.353，P=0.012、0.010、0.007）。BMI与肝脏SUVmax-B （r=0.543，P<0.01）、SUVmax-L （r=0.328，P=0.07）呈正相关BMI与SUVmax-S无相关性（r=0.026，P=0.833）。受检者年龄、肝脏CT值与肝脏SUVmax-B、SUVmax-L、SUVmax-S均无相关性（P均>0.05）。男性肝脏SUVmax-B （t=2.608，P=0.011）、SUVmax-L （t=5.272，P<0.001）明显高于女性，男性与女性肝脏SUVmax-S无统计学差异（t=0.759，P=0.450）。脂肪肝受检者与非脂肪肝受检者肝脏SUVmax-B、SUVmax-L、SUVmax-S均无统计学差异（P=0.646、0.775、0.068）。结论 空腹血糖水平、BMI、性别是PET/CT显像中影响肝脏摄取18F-FDG的因素。BMI较大的受检者可采用SUVmax-L或SUVmax-S代替SUVmax-B，此外SUVmax-S可弥补性别间的差异，但校正技术无法减弱血糖水平对肝脏SUVmax的影响。 |
| 英文摘要: |
| Objective To explore the impact factors of liver uptake of 18F-FDG in PET/CT imaging, and to preliminary analyze the application of maximum standardized uptake values corrected by conventional body mass, lean body mass and body surface area (SUVmax-B, SUVmax-L, SUVmax-S).Methods A retrospective analysis was performed on 67 healthy subjects who underwent 18F-FDG PET/CT. SUVmax-B, SUVmax-L and SUVmax-S were measured, and the impact of age, levels of fasting blood glucose, body mass index (BMI), CT value of liver, gender and the fatty liver on SUVmax-B, SUVmax-L and SUVmax-S were analyzed.Results The liver SUVmax-B, SUVmax-L, SUVmax-S were positively correlated with the levels of fasting blood glucose (r=0.329, 0.336, 0.353, P=0.012, 0.010, 0.007). There was a positive correlation between BMI and SUVmax-B (r=0.543, P<0.01), SUV-L (r=0.328, P=0.007), while BMI value had no correlation with SUVmax-S (r=0.026, P=0.833). There was no correlation between age, CT value of the liver nor SUVmax-B, SUVmax-L and SUVmax-S (all P>0.05). The liver SUVmax-B (t=2.608, P=0.011) and SUVmax-L (t=5.272, P=0.001) of male were significantly higher than those of female, while there was no difference between male's and female's liver SUVmax-S and liver SUVmax-S (t=0.759, P=0.450). There was no difference in SUVmax-B, SUVmax-L nor SUVmax-S between fatty liver subjects and non-fatty liver subjects (P=0.646, 0.775, 0.068).Conclusion The fasting blood glucose level, BMI and sex are the impact factors of liver uptake of 18F-FDG in PET/CT imaging. SUVmax-B can be replaced by SUVmax-L or SUVmax-S for larger BMI subjects, while SUVmax-S can make up differences between different genders. However, correction techniques can not weaken the impact of blood glucose level on SUVmax value of liver. |
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