| 刘影,许璐,周静,刘倩,李文波,庞华.18F-FDG PET/CT代谢体积参数对Ⅱ~Ⅲ期[J].中国医学影像技术,2017,33(8):1211~1215 |
| 18F-FDG PET/CT代谢体积参数对Ⅱ~Ⅲ期 |
| Prognosis of metabolic volume parameters by 18F-FDG PET/CT in stageⅡ-Ⅲ non-small cell lung cancer |
| 投稿时间：2016-11-18 修订日期：2017-04-08 |
| DOI：10.13929/j.1003-3289.201611090 |
| 中文关键词: 癌,非小细胞肺 放射性核素显像 体层摄影术,X线计算机 预后 |
| 英文关键词:Carcinoma,non-small-cell lung Radionuclide imaging Tomography,X-ray computed Prognosis |
| 基金项目:临床重点专科建设项目（国卫办医函[2013]544号） |
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| 中文摘要: |
| 目的 评估基于18F-FDG PET/CT的肿瘤代谢体积（MTV）和糖酵解总量（TLG）对Ⅱ~Ⅲ期非小细胞肺癌（NSCLC）患者的预后价值。方法 回顾性分析治疗前接受18F-FDG PET/CT检查并经病理确诊的47例Ⅱ、Ⅲ期NSCLC患者的资料。采用Kaplan-Meier法、Log-rank检验及COX比例风险模型分析代谢体积参数、总生存期（OS）和无进展生存期（PFS）的关系。MTV的测量以40%最大标准化摄取值（SUVmax）为阈值。结果 所有患者中位OS为28.93个月，中位PFS为17.37个月；1年、2年、3年整体生存率分别为80.85%（38/47）、59.57%（28/47）、38.30%（18/47）。单因素分析显示SUVmax、MTV、TLG与OS和PFS均有关系（P均<0.05）；多因素分析显示高TLG是PFS的危险因素（HR=5.591，P<0.001），高MTV是OS的危险因素（HR=4.369，P<0.001）。MTV与TNM分期存在相关性（r=0.449，P=0.012）。结论 MTV是Ⅱ、Ⅲ期NSCLC患者整体生存的独立预测因素，TLG则可预测Ⅱ、Ⅲ期NSCLC患者疾病进展。 |
| 英文摘要: |
| Objective To evaluate the prognostic value of 18F-FDG PET/CT-based metabolic tumor volume (MTV) and total lesion glycolysis (TLG) in stage Ⅱ-Ⅲ non-small cell lung cancer (NSCLC).Methods All of 47 patients with pathological stage on Ⅱ or Ⅲ NSCLC who underwent PET/CT before treatment were retrospectively reviewed.Kaplan-Meier method,Log-rank test and COX proportional hazard model were used to analyze the relationship between metabolic parameters and overall survival (OS),progression free survival (PFS).MTV were measured using a cutoff of 40% maximum standard uptake value (SUVmax).Results The median OS and PFS was 28.93 and 17.37 months,and the 1-,2-and 3-year overall survival rate was 80.85%(38/47),59.57%(28/47),38.30%(18/47),respectively.Univariate analysis suggested that SUVmax,MTV and TLG had significant differences on OS and PFS (all P<0.05).On multivariate analysis,TLG was a risk factor for PFS (HR=5.591,P<0.001),and MTV was a risk factor for OS (HR=4.369,P<0.001).MTV was correlated with TNM-staging (r=0.449,P=0.012).Conclusion In patients with stage Ⅱ or Ⅲ NSCLC,MTV is a independent significant prognostic factor for OS,and TLG is able to predict the progression. |
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