| 潘海鹏,劳群,费正华,杨丽,周海春,李群英,赖灿.实验兔皮内、皮下注射钆双胺行间质MR淋巴管成像对脊柱旁淋巴干显像的对比分析[J].中国医学影像技术,2017,33(8):1167~1170 |
| 实验兔皮内、皮下注射钆双胺行间质MR淋巴管成像对脊柱旁淋巴干显像的对比分析 |
| Comparative analysis of paravertebral lymphatic trunk by MR lymphangiography between intradermal and subcutaneous injection of Gadodiamide in rabbits |
| 投稿时间：2017-01-05 修订日期：2017-04-24 |
| DOI：10.13929/j.1003-3289.201701026 |
| 中文关键词: 磁共振成像 淋巴管造影术 钆双胺 实验研究 |
| 英文关键词:Magnetic resonance imaging Lymphography Gadodiamide Experimental study |
| 基金项目:2014年浙江省医药卫生科技计划项目（2014KYA121） |
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| 中文摘要: |
| 目的 探讨经兔足背皮内、皮下注射钆双胺行脊柱旁淋巴干MR成像的可行性。方法 选取新西兰大白兔8只，首先经足背皮内注射钆双铵（皮内组），间隔3天后再经皮下注射（皮下组），采集冠状位三维扰相梯度回波序列（fl3d-cor）图像，分别评价腰淋巴干及胸导管的显示情况。结果 皮内组显示所有兔两侧腘窝淋巴结、髂淋巴结及主动脉下淋巴结明显强化，强化持续时间大于30 min，最长达90 min；6例腰淋巴干全程及乳糜池明显强化；5例可见部分胸导管强化。皮下组显示所有兔两侧腘窝淋巴结均明显强化，但腰淋巴结、腰淋巴干及胸导管未见强化。腰淋巴干及胸导管强化程度总评分皮内组与皮下组差异有统计学意义（t=100.00，P=0.0002）。结论 足背皮内注射钆双胺淋巴管成像能较皮下注射更好地显示腰干淋巴管。 |
| 英文摘要: |
| Objective To investigate intradermal injection and subcutaneous injection of Gadodiamide MR lymphangiography (MRL) in evaluation on the central conducting lymphatics in rabbits.Methods T1 weighted three-dimendional fast low angle shot (fl3d) sequence was used before and after administration of Gadodiamide to undertake MRL.Gadodiamide was administed intrademally in the left and right footpad in 8 rabbits,and then undertake MRL in 1.5T MRI system (intradermal injection group).Three days later,Gadodiamide was administered subcutaneously in the left and right footpad in 8 rabbits,and MRL were underdone with the same sequence (subcutaneous injection group).The degree of contrast enhancement within the lumbar lymphatic trunk and thoracic duct were evaluated using a 3-point scoring system.Results Intradermal injection group showed the popliteal lymph nodes,sacral lymph node and inferior aortic lymph node enhanced obviously in all 8 rabbits,and the enhancement duration time was about 30-90 min;the lumbar lymphatic trunk and cisterna chyli were detected in 6 rabbits,and part of the thoracic duct were detected in 5 rabbits.Subcutaneous injection group showed the popliteal lymph nodes enhanced obviously in all 8 rabbits,but the lumbar lymphatic trunk and the thoracic duct were not detected.The score of contrast enhancement within the lymphatic system of intradermal injection group and subcutaneous injection group had statistical difference (t=100.00, P=0.0002).Conclusion MRL with intradermal injection Gadodiamide are better than subcutaneous injection in evaluation of the lumbar lymphatic trunk. |
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