| 郑阳,王晓明.新生猪缺氧缺血脑损伤后酰胺质子转移成像[J].中国医学影像技术,2017,33(8):1153~1157 |
| 新生猪缺氧缺血脑损伤后酰胺质子转移成像 |
| Amide proton transfer imaging of neonatal piglet with hypoxic ischemic brain injury |
| 投稿时间：2017-01-07 修订日期：2017-02-16 |
| DOI：10.13929/j.1003-3289.201611080 |
| 中文关键词: 脑损伤 缺氧缺血,脑 新生猪 酰胺质子转移 |
| 英文关键词:Brain injuries Hypoxia-ischemia,brain Piglet Amide proton transfer |
| 基金项目:国家自然科学基金（30570541、30770632、81271631）、盛京医院自由研究者基金（201402）。 |
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| 中文摘要: |
| 目的 探讨不同时间点新生猪缺氧缺血脑损伤（HIBI）模型酰胺质子转移（APT）成像基底核APT值的变化。方法 选用出生后3~5天的健康新生猪35只，分为对照组（n=5）及模型组（n=30），分别进行假手术（对照组）及HIBI建模操作。其中模型组依据MR扫描和建立HIBI模型的间隔时间分为0~< 2 h、2~< 6 h、6~< 12 h、12~< 24 h、24~< 48 h、48~< 72 h亚组。对各组均行APT成像，测量双侧基底核APT值。比较对照组及模型组各亚组间基底核APT值的差异。结果 新生猪HIBI后0~2 h，APT值出现急剧下降，随后逐渐升高，24 h左右基本恢复至对照组水平。对照组及模型组0~< 2 h、2~< 6 h、6~< 12 h、12~< 24 h、24~< 48 h、48~< 72 h亚组平均APT值分别为0.52±0.09、-0.35±0.08、-0.02±0.14、0.28±0.04、0.46±0.11、0.80±0.11、1.24±0.18。除12~<24 h亚组外（P=0.68），模型组其余各亚组与对照组间APT值差异均有统计学意义（P均<0.01）。结论 APT值在新生猪HIBI后呈现先下降后上升的变化趋势，有望为今后进一步临床研究HIBI患儿脑内病理生理变化提供参考依据。 |
| 英文摘要: |
| Objective To investigate the amide proton transfer (APT) values in basal ganglia of neonatal piglet hypoxic-ischemic brain injury (HIBI) model using MR APT imaging.Methods Totally 35 healthy neonatal piglets were selected.There were 5 piglets underwent sham-operation in control group and 30 piglets used to established HIBI models in HIBI group.According to the time interval between APT imaging and the establishment of HIBI model,the piglets in HIBI group were divided into 0-< 2 h,2-< 6 h,6-< 12 h,12-< 24 h,24-< 48 h and 48-< 72 h subgroups.APT imaging was performed on all piglets.The APT value of basal ganglia between control group and all the subgroups in HIBI group were compared.Results After HIBI occurred,the APT values immediately decreased in 0-2 h,and then increased gradually.In 24 h after HIBI,the APT values were mainly returned to the level of control group,then continuously increased.The APT value in control group and 0-< 2 h,2-< 6 h,6-< 12 h,12-< 24 h,24-< 48 h,48-< 72 h subgroups in HIBI group were 0.52±0.09,-0.35±0.08,-0.02±0.14,0.28±0.04,0.46±0.11,0.80±0.11,1.24±0.18,respectively.The APT values between control group and each subgroups in HIBI group had significant differences (all P<0.01) except for 12-<24 h subgroup (P=0.68).Conclusion The APT value decreased firstly and then increased after HIBI in neonatal piglet.APT imaging can provide a non-invasive molecular MR method to evaluate the pathophysiological changes of HIBI. |
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