| 喻思思,俞瑶涵,唐雪培,邹倩,李淑豪,郑甜,龚良庚.MR特征追踪技术定量评估肥厚型心肌病心肌应变[J].中国医学影像技术,2017,33(8):1129~1133 |
| MR特征追踪技术定量评估肥厚型心肌病心肌应变 |
| Cardiac MR feature tracking in detection of left ventricular myocardial strain in hypertrophic cardiomyopathy |
| 投稿时间：2017-03-13 修订日期：2017-06-30 |
| DOI：10.13929/j.1003-3289.201703062 |
| 中文关键词: 心肌病,肥厚型 磁共振成像 特征追踪 心肌应变 |
| 英文关键词:Cardiomyopathy,hypertrophic Magnetic resonance imaging Feature tracking Myocardial strain |
| 基金项目:国家自然科学基金（81660284、81360216）、江西省自然科学基金（20161ACB20013、20142BAB205061） |
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| 中文摘要: |
| 目的 探讨MR特征追踪技术（CMR-FT）定量分析肥厚型心肌病（HCM）左心室整体和局部心肌应变的临床价值。方法 收集HCM患者60例（HCM组）及健康志愿者10名（对照组）。所有受检者均接受心脏MR检查，扫描序列包括心室短轴、二腔心、四腔心层面快速平衡稳态进动序列（FIESTA）和延迟增强扫描（LGE）。HCM组按有无强化分为无强化亚组和有强化亚组。采用CMR-FT后处理软件测定心肌整体的径向应变峰值（GPSR）、环向应变峰值（GPSC）、纵向应变峰值（GPSL）以及心室不同部位（心尖部、心室中部和基底部）的径向、环向和纵向应变峰值（PSR、PSC和PSL）。结果 有强化亚组、无强化亚组和对照组的GPSR、GPSC和GPSL差异有统计学意义（P均<0.05），呈增高趋势。除心尖部PSL 3组间差异无统计学意义外，有强化亚组、无强化亚组和对照组的PSR、PSC和PSL差异均有统计学意义（P均<0.05），在心脏各部位均呈上升趋势。LVEF、SV与GPSR、GPSC、GPSL均呈正相关（P均<0.05）。GPSR、GPSC、GPSL诊断HCM的ROC曲线下面积分别为0.79、0.82、0.77（P均<0.05），其中GPSC的曲线下面积最大。结论 CMR-FT技术能够早期敏感地发现HCM的心肌应变功能障碍，且纵向应变受损早于或重于环向应变及径向应变。 |
| 英文摘要: |
| Objective To explore clinical value of cardiac MRI feature tracking (CMR-FT) in evaluation of left ventricular global and regional myocardial strain in hypertrophic cardiomyopathy (HCM).Methods Totally 60 patients with HCM (HCM group) and 10 healthy volunteers (control group) were enrolled and underwent cardiac MR.MR Sequences included fast imaging employing steady-state acquisition (FIESTA) and late gadalinum enhancement (LGE) at ventricular short-axis,two-chamber and four-chamber planes.The patients in HCM group were divided into LGE negative subgroup and LGE positive subgroup.CMR-FT processing software was used to measure myocardial global radial peak strain (GPSR),global circumferential peak strain (GPSC) and global longitudinal peak strain (GPSL).The radial,circumferential and longitudinal peak strain (PSR,PSC and PSL) at the apex,middle and basal parts of left ventricular were also measured as well.Results GPSR,GPSC,GPSL in LGE positive subgroup,LGE negative subgroup and control group had significant differences (all P<0.05),and showed upward trends.Except PSL at the apex had no significent difference among three groups,PSR,PSC and PSL at the apex,middle and basal parts had significant differences (all P<0.05),and also showed upward trends.There were positive correlations between the LVEF,SV and GPSR,GPSC,GPSL (all P<0.05).The area under ROC curve of GPSR,GPSC and GPSL in diagnosis of HCM were 0.79,0.82,0.77(all P<0.05),and the area under ROC curve of GPSC was the largest.Conclusion The CMR-FT technology can find myocardial strain dysfunction in HCM sensitively,and the longitudinal strain is damaged earlier or worse than circumferential and radial strains. |
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