| 曹莉培,王正阁,张冰.青少年肌阵挛癫痫丘脑-皮质网络的磁共振波谱研究进展[J].中国医学影像技术,2017,33(6):954~958 |
| 青少年肌阵挛癫痫丘脑-皮质网络的磁共振波谱研究进展 |
| Progresses of magnetic resonance spectroscopy in thalamo-cortical network of juvenile myoclonic epilepsy |
| 投稿时间：2016-07-13 修订日期：2017-04-24 |
| DOI：10.13929/j.1003-3289.201607060 |
| 中文关键词: 青少年 癫痫,肌阵挛 磁共振波谱成像 丘脑-皮质网络 |
| 英文关键词:Juvenile Epilepsies, myoclonic Magnetic resonance spectroscopy Thalamo-cortical network |
| 基金项目:国家自然科学基金青年基金（81301198、81300925）、国家自然科学基金面上项目（81571040）。 |
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| 中文摘要: |
| 青少年肌阵挛癫痫是一种特发性全面性癫痫综合征，对其诊断主要依靠病史、临床症状和脑电图，常规影像学检查未见脑内器质性病变。MRS可无创地定量测定脑内神经代谢物浓度，评估患者大脑代谢改变。目前，丘脑-皮质网络功能障碍是本病的研究热点，该网络中存在神经代谢物浓度改变以及神经递质谷氨酸和γ-氨基丁酸代谢失衡。而癫痫的发病与脑内兴奋性和抑制性氨基酸的比例失衡有关，且癫痫发作可引起神经元损伤，导致神经元相关代谢产物浓度改变。本文将物质代谢、神经结构和功能相结合，对青少年肌阵挛癫痫患者的磁共振波谱研究进行综述。 |
| 英文摘要: |
| Juvenile myoclonic epilepsy (JME) diagnosed with seizure history, semiology and electroencephalography is a syndrome of idiopathic generalized epilepsy. MRS can quantitatively detect the concentration of neurometabolites noninvasively, and assess the metabolic changes in brain. Currently, studies of pathogenesis of JME are focused on the dysfunction of thalamo-cortical network and the neurometabolites and imbalance of Glutamate and γ-aminobutyric acid in the network are alterted. Epilepsy is associated with the imbalance of the ratio of excitatory and inhibitory amino acid, and seizures lead to neuronal lesions which result in altered concentration of neuron related metabolites. This article reviewed MRS studies of JME by combining material metabolism, neural structure and function. |
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