| 赵娓娓,任静,印弘,宦怡.动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性[J].中国医学影像技术,2017,33(6):893~896 |
| 动态增强磁共振成像定量评估健康志愿者胰腺灌注的可行性 |
| Feasibility of quantitative assessment of pancreatic perfusion with dynamic contrast-enhanced MRI in healthy volunteers |
| 投稿时间：2016-09-27 修订日期：2017-03-16 |
| DOI：10.13929/j.1003-3289.201609129 |
| 中文关键词: 胰腺 灌注成像 磁共振成像 对比剂 定量参数 |
| 英文关键词:Pancreas Perfusion imaging Magnetic resonance imaging Contrast media Quantitative parameters |
| 基金项目:国家自然科学基金（81220108011）。 |
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| 中文摘要: |
| 目的 探讨动态增强磁共振成像（DCE-MRI）量化评估胰腺灌注的可行性。方法 将68名健康志愿者分为青年组、中年组和老年组。对所有志愿者均行DCE-MRI,将数据传至Research-DCEMRI Tool诊断分析工作站,计算胰腺灌注的定量参数：容积转运常数（Ktrans）、间质-血浆速率常数（Kep）、间质容积（Ve）和血浆容积（Vp）。采用两独立样本t检验和单因素方差分析评估不同性别、年龄组和胰腺部位的灌注参数。结果 不同性别志愿者Ktrans、Kep、Ve和Vp差异均无统计学意义（P均>0.05）；老年组Ve高于青年组和中年组（P=0.036、0.001）；胰头区Vp高于胰体部和胰尾部（P=0.011、0.023）。结论 DCE-MRI可无创、较稳定、定量评估胰腺灌注情况。胰腺DCE-MRI定量灌注参数不随性别差异而不同,但随年龄和胰腺部位的不同而有差异。 |
| 英文摘要: |
| Objective To explore the feasibility of quantitative assessment of pancreatic perfusion using dynamic contrast-enhanced MRI (DCE-MRI). Methods Totally 68 healthy volunteers were divided into youth, middle and old groups according to ages. All volunteers underwent pancreas DCE-MRI examination. Images were transmitted to Research-DCE MRI Tool workstation to calculate the quantitative parameters, including volume transfer constant (Ktrans), interstitium-to-plasma rate constant (Kep), interstitial volume (Ve) and plasma volume (Vp). Independent sample t test and one-way ANOVA test were used to evaluate the differences of pancreatic perfusion. Results There were no significant differences of Ktrans, Kep, Ve and Vp between male and female; Ve in old group was higher than that in youth and middle groups (P=0.036, 0.001); Vp of pancreatic head was higher than that of pancreatic body and tail (P=0.011, 0.023). Conclusion DCE-MRI can be applied to provide a reliable quantitative assessment of pancreatic perfusion noninvasively. The parameters of DCE-MRI of pancreatic perfusion are independent of gender but vary with age and pancreatic sites. |
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