| 董智芬,张迎春,盛余敬,王才善,张英,胡华,罗蔚锋,刘春风.帕金森病与阿尔茨海默病患者的经颅超声图像分析[J].中国医学影像技术,2017,33(4):514~517 |
| 帕金森病与阿尔茨海默病患者的经颅超声图像分析 |
| Transcranial sonography in patients with Parkinson disease and Alzheimer disease |
| 投稿时间：2016-10-09 修订日期：2017-01-03 |
| DOI：10.13929/j.1003-3289.201610021 |
| 中文关键词: 帕金森病 阿尔茨海默病 超声检查,多普勒,经颅 |
| 英文关键词:Parkinson disease Alzheimer disease Ultrasonography, Doppler, transcranial |
| 基金项目:江苏省临床医学科技专项（BL2014042）、江苏省普通高校研究生实践创新计划项目（SJLX15_0578）、苏州市科技发展计划项目（SYSD2015082）。 |
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| 中文摘要: |
| 目的 对比分析帕金森病（PD）和阿尔茨海默病（AD）患者的经颅超声（TCS）图像变化特点。方法 对38例PD、28例AD及26名健康志愿者行TCS检查，分析其黑质回声、3脑室宽度及大脑中动脉血流参数变化特点。结果 黑质异常强回声比例PD组（31/38，81.58%）高于AD组（8/28，28.57%）和对照组（3/26，11.54%），差异均有统计学意义（χ2=18.74、30.41，P均<0.001），而AD组和对照组间无明显差异（χ2=2.41，P=0.120）；3脑室宽度AD组[（0.82±0.14）cm]大于PD组[（0.63±0.16）cm]和对照组[（0.56±0.16）cm]，差异均有统计学意义（P均<0.001），而PD组和对照组间差异无统计学意义（P=0.098）；双侧大脑中动脉平均流速AD组均低于PD组和对照组，右侧大脑中动脉搏动指数AD组高于PD组和对照组，差异均有统计学意义（P均<0.05）。结论 通过TCS检查，联合黑质回声、3脑室宽度及大脑中动脉血流变化，可为PD及AD的诊断提供有价值的神经影像学信息。 |
| 英文摘要: |
| Objective To assess the features of transcranial sonography (TCS) in Parkinson disease (PD) and Alzheimer disease (AD). Methods Totally 38 PD patients (PD group), 28 AD patients (AD group) and 26 controls (control group) underwent TCS. The echogenicity of the substantia nigra, widths of third ventricle and parameters of middle cerebral artery among the three groups were analyzed. Results The ratio of hyperechogenicity of substantia nigra in PD group (31/38, 81.58%) were higher than those in AD group (8/28, 28.57%) and control group (3/26, 11.54%; χ2=18.74, 30.41, both P<0.001), and there was no significant difference in hyperechogenicity of substantia nigra between AD group and control group (χ2=2.41, P=0.120). The widths of third ventricle in AD group ([0.82±2014]cm) were wider than those in PD group ([0.63±0.16]cm) and control group ([0.56±0.16]cm, both P<0.001), and there was no significant difference in widths of third ventricle between PD group and control group (P=0.098). The mean velocities in bilateral middle cerebral artery in AD group were lower than that of in PD group and in control group (all P<0.05). The pulsatility index in right middle cerebral artery in AD group were greater than that in PD group and control group (both P<0.05). Conclusion According to the changes of echogenicity of substantia nigra, widths of third ventricle and parameters of middle cerebral artery, TCS may provide some useful information for diagnosis of PD and AD. |
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